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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genotoxic responses of juvenile tilapia (Oreochromis niloticus) exposed to florfenicol and oxytetracycline

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Botelho, R. G. [1] ; Christofoletti, C. A. [2] ; Correia, J. E. [3] ; Ansoar, Y. [3] ; Olinda, R. A. [4] ; Tornisielo, V. L. [1]
Total Authors: 6
[1] Univ Sao Paulo, Ctr Energia Nucl Agr, Lab Ecotoxicol Aquat, BR-13416000 Piracicaba, SP - Brazil
[2] FHO UNIARARAS, Ctr Univ Herminio Ometto, BR-13607339 Sao Paulo - Brazil
[3] Univ Estadual Paulista, BR-13506900 Sao Paulo - Brazil
[4] Univ Estadual Paraiba, UEPB, Ctr Ciencias Tecnol, Dept Estat, BR-58101001 Campina Grande, Paraiba - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Chemosphere; v. 132, p. 206-212, AUG 2015.
Web of Science Citations: 19

Florfenicol (FLC) and oxytetracycline (OTC) are the two most commonly used antibiotics for bacterial treatment in fish farming in Brazil, and because of their intensive use, the potential harmful effects on aquatic organisms are of great concern. This study evaluated the effects of environmental concentrations of FLC and OTC on the genetic material of juvenile tilapia (Oreochromis niloticus) erythrocytes by using the comet assay and the occurrence of micronuclei (MN) and other erythrocytic nuclear abnormalities (ENAs) after exposure to 96 hour. The comet assay showed that fish erythrocytes exhibited significantly higher DNA damage after exposure to environmental concentrations of FLC and OTC. Although MN was not observed, ENAs were significantly higher after exposure to FLC, indicating that ENAs are a better biomarker for FLC than MN. The results showed that environmental concentrations of FLC and OTC were genotoxic to erythrocytes of O. niloticus; however, future studies on DNA damage recovery are needed. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/08143-5 - Effects of environmental concentration of the antibiotics oxytetracycline and florfenicol in fishes.
Grantee:Rafael Grossi Botelho
Support type: Scholarships in Brazil - Post-Doctorate