Advanced search
Start date
Betweenand

Combination of thiamphenicol with florfenicol: pharmacokinetics and therapeutic efficacy in the treatment of Streptococcosis in Nile Tilapia (Oreochromis niloticus)

Grant number: 19/22775-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2020
Effective date (End): May 31, 2022
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
Principal Investigator:Fabiana Pilarski
Grantee:Inácio Mateus Assane
Host Institution: Centro de Aquicultura (CAUNESP). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Brazilian aquaculture production has increased significantly in the last two decades, mainly Tilapia Tilapia breeding. However, outbreaks of bacterial diseases have led to major economic losses; resulting in increased risks and uncertainties about the future of the activity and reduced investment. Given this situation, and the scarcity of effective therapeutic alternatives for the control of disease outbreaks, several antimicrobials are used illegally and inappropriately; resulting in therapeutic inefficacy of available antimicrobials, emergence and dispersion of antimicrobial resistance in fish farming. There are currently only two antibiotics approved for use in Aquaculture in Brazil, oxytetracycline and florfenicol (FFC), and only FFC is approved for the treatment of diseases in Tilapia. Given this scenario, the search for effective therapeutic alternatives for the treatment of bacterial diseases in fish farming is a necessity. Thus, we are going to study the pharmacokinetics (plasma) profile of thiamphenicol (TAP), FFC and florfenicol amine (FFCA) in Nile Tilapia after administration of the combination TAP-FFC; and the therapeutic efficacy of this combination in the treatment of Streptococcosis (caused by Streptococcus spp.) in Nile Tilapia. Streptococcosis is among the main diseases that affect Tilapia production (from fry (10g) to adult (1kg)). Satisfactory results on the therapeutic efficacy of the TAP: FFC combination in the treatment of various bacterial diseases in various species of livestock, including fish, suggest the potential of this combination as a therapeutic alternative for the treatment of bacterial diseases in Nile Tilapia. The results of this research are expected to contribute to the establishment of an effective Streptococcosis treatment protocol using the TAP: FFC combination in Tilapia. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VANECI-SILVA, DAIANE; ASSANE, INACIO MATEUS; ALVES, LINDOMAR DE OLIVEIRA; GOMES, FERNANDO CARDOSO; MORO, EVANDRO BILHA; KOTZENT, SUZANA; SILVA, ANDRE PITONDO; PILARSKI, FABIANA. Klebsiella pneumoniae causing mass mortality in juvenile Nile tilapia in Brazil: Isolation, characterization, pathogenicity and phylogenetic relationship with other environmental and pathogenic strains from livestock and human sources. Aquaculture, v. 546, . (19/22775-0)
FERREIRA, DANIEL DE ABREU REIS; ASSANE, INACIO MATEUS; VANECI-SILVA, DAIANE; OLIVEIRA, ANDRE DO VALE; TAMASHIRO, GEOVANA DOTTA; HASHIMOTO, DIOGO TERUO; PILARSKI, FABIANA. Morpho-molecular identification, pathogenicity for Piaractus mesopotamicus, and antimicrobial susceptibility of a virulent Flavobacterium columnare isolated from Nile tilapia cultured in Brazil. Aquaculture, v. 560, p. 10-pg., . (18/24499-8, 19/22775-0)
ASSANE, INACIO MATEUS; PRADA-MEJIA, KAREN DAYANA; GALLANI, SILVIA UMEDA; WEISER, NATASHA FERNANDES; RAMOS VALLADAO, GUSTAVO MORAES; PILARSKI, FABIANA. Enterogyrus spp. (Monogenea: Ancyrocephalinae) and Aeromonas jandaei co-infection associated with high mortality following transport stress in cultured Nile tilapia. TRANSBOUNDARY AND EMERGING DISEASES, . (19/22775-0)
ASSANE, I. M.; SANTOS-FILHO, N. A.; DE SOUSA, E. L.; DEARRUDA BRASIL, M. C. O.; CILLI, E. M.; PILARSKI, F.. Cytotoxicity and antimicrobial activity of synthetic peptides alone or in combination with conventional antimicrobials against fish pathogenic bacteria. Journal of Applied Microbiology, v. 131, n. 4, p. 1762-1774, . (19/22775-0)
ASSANE, INACIO M.; VALLADAO, GUSTAVO M. R.; PILARSKI, FABIANA. Chemical composition, cytotoxicity and antimicrobial activity of selected plant-derived essential oils against fish pathogens. AQUACULTURE RESEARCH, v. 52, n. 2, p. 793-809, . (19/22775-0)
DE SOUSA, ELIELMA LIMA; ASSANE, INACIO MATEUS; SANTOS-FILHO, NORIVAL ALVES; CILLI, EDUARDO MAFFUD; DE JESUS, RAPHAEL BARBETTA; PILARSKI, FABIANA. Haematological, biochemical and immunological biomarkers, antibacterial activity, and survival in Nile tilapia Oreochromis niloticus after treatment using antimicrobial peptide LL-37 against Streptococcus agalactiae. Aquaculture, v. 533, . (19/22775-0)
DE FREITAS, LUCAS VICTOR PEREIRA; DA MOTA, CARLOS AUGUSTO ALVARENGA; DAMACENO, MARINA ALVES; SILVEIRA, JULIANA GRELL FERNANDES; PORTELA, ANA CAROLINA VELLOSA; CAMPANHARO, SARAH CHAGAS; DA SILVA, AGNALDO FERNANDO BALDO; ASSANE, INACIO MATEUS; PILARSKI, FABIANA; SASANYA, JAMES JACOB; et al. Residue Depletion Profile and Estimation of Withdrawal Period for Sulfadimethoxine and Ormetoprim in Edible Tissues of Nile Tilapia (Oreochromis sp.) on Medicated Feed. ANIMALS, v. 13, n. 15, p. 13-pg., . (21/03294-1, 19/06159-8, 16/16593-9, 18/05536-0, 21/08152-0, 19/22775-0, 12/18334-0)
ASSANE, INACIO MATEUS; DAMACENO, MARINA ALVES; CAMPANHARO, SARAH CHAGAS; DA SILVA, AGNALDO FERNANDO BALDO; DE SOUSA, ELIELMA LIMA; OLIVEIRA, ANDRE DO VALE; FERREIRA, DANIEL DE ABREU REIS; KOTZENT, SUZANA; DE JESUS, RAPHAEL BARBETTA; DA PAZ, DEBORAH JACOB FREIRE; et al. Thiamphenicol and florfenicol combination in Nile tilapia: Simultaneous detection and quantification in plasma and muscle plus skin samples, and pharmacokinetics following single oral administration. Aquaculture, v. 577, p. 11-pg., . (18/05536-0, 19/22775-0, 19/06159-8)
ASSANE, I. M.; SANTOS-FILHO, N. A.; DE SOUSA, E. L.; DEARRUDA BRASIL, M. C. O.; CILLI, E. M.; PILARSKI, F.. Cytotoxicity and antimicrobial activity of synthetic peptides alone or in combination with conventional antimicrobials against fish pathogenic bacteria. Journal of Applied Microbiology, . (19/22775-0)
CAMPANHARO, SARAH CHAGAS; DA SILVA, AGNALDO FERNANDO BALDO; BLEUZEN, ANAIS; DA SILVA, JONAS JOAQUIM MANGABEIRA; DE FREITAS, LUCAS VICTOR PEREIRA; ASSANE, INACIO MATEUS; PILARSKI, FABIANA; PASCHOAL, JONAS AUGUSTO RIZZATO. The association of modified QuEChERS and DLLME to offer high analytical detectability to assess residual depletion profile of erythromycin in fish. Food Chemistry, v. 405, p. 8-pg., . (12/18334-0, 19/06159-8, 17/15052-7, 18/05536-0, 19/22775-0, 21/03294-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ASSANE, Inácio Mateus. Potential of plant-derived essential oils, antimicrobial peptides and combination of antimicrobials against fish bacterial pathogens. 2022. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

Please report errors in scientific publications list using this form.