Thermal behavior and decomposition of oxytetracycline hydrochloride

Author(s)

Cervini, Priscila ^[1] ; Ambrozini, Beatriz ^[1] ; Machado, Luis Carlos M. ^[1] ; Garcia Ferreira, Ana Paula ^[1] ; Gomes Cavalheiro, Eder Tadeu ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 121, n. 1, p. 347-352, JUL 2015.
• Web of Science Citations: 4

Abstract

The thermal behavior of oxytetracycline hydrochloride (OTC) antibiotic was evaluated using TG-DTA, TG-FTIR and DSC. Information was obtained regarding thermal stability and decomposition steps. From TG-FTIR, it was possible to identify some of the products of its thermal decomposition as chloridric acid, water, isocyanic acid, dimethylamine, methane, carbonic gas and ammonia, and carbon dioxide from the decomposition of the isocyanic acid. According to DSC data, melting occurred concomitantly with decomposition. The TG/DTG, DTA and DSC curves, together with the FTIR spectra of the volatile decomposition products, were used to propose a mechanism for oxytetracycline decomposition. (AU)

• FAPESP's process: 12/09911-3 - Application of thermal analysis to the study of antihypertensives and antibiotics drugs: beta-blockers and tetracyclines
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants