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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta

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Author(s):
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Ataide, Ricardo [1, 2] ; Murillo, Oscar [1] ; Dombrowski, Jamille G. [1] ; Souza, Rodrigo M. [1, 3] ; Lima, Flavia A. [1] ; Lima, Giselle F. M. C. [4] ; Hristov, Angelica D. [4] ; Valle, Suiane C. N. [3] ; Di Santi, Silvia M. [4] ; Epiphanio, Sabrina [5] ; Marinho, Claudio R. F. [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP - Brazil
[2] Burnet Inst, Ctr Biomed Res, Melbourne - Australia
[3] Univ Fed Acre, Ctr Multidisciplinar, Cruzeiro Do Sul, Acre - Brazil
[4] Univ Sao Paulo, Nucleo Estudos Malaria, Superintendencia Controle Endemias, Inst Med Trop Sao Paulo IMT, BR-09500900 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo FCF USP, Dept Anal Clin & Toxicol, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PLoS Neglected Tropical Diseases; v. 9, n. 6 JUN 2015.
Web of Science Citations: 13
Abstract

Malaria in pregnancy remains a substantial public health problem in malaria-endemic areas with detrimental outcomes for both the mother and the foetus. The placental changes that lead to some of these detrimental outcomes have been studied, but the mechanisms that lead to these changes are still not fully elucidated. There is some indication that imbalances in cytokine cascades, complement activation and angiogenic dysregulation might be involved in the placental changes observed. Nevertheless, the majority of studies on malaria in pregnancy (MiP) have come from areas where malaria transmission is high and usually restricted to Plasmodium falciparum, the most pathogenic of the malaria parasite species. We conducted a cross-sectional study in Cruzeiro do Sul, Acre state, Brazil, an area of low transmission and where both P. vivax and P. falciparum circulate. We collected peripheral and placental blood and placental biopsies, at delivery from 137 primigravid women and measured levels of the angiogenic factors angiopoietin (Ang)-1, Ang-2, their receptor Tie-2, and several cytokines and chemokines. We measured 4 placental parameters (placental weight, syncytial knots, placental barrier thickness and mononuclear cells) and associated these with the levels of angiogenic factors and cytokines. In this study, MiP was not associated with severe outcomes. An increased ratio of peripheral Tie-2: Ang-1 was associated with the occurrence of MiP. Both Ang-1 and Ang-2 had similar magnitudes but inverse associations with placental barrier thickness. Malaria in pregnancy is an effect modifier of the association between Ang-1 and placental barrier thickness. (AU)

FAPESP's process: 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria
Grantee:Cláudio Romero Farias Marinho
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 11/20921-8 - Malaria in pregnancy: a study of Plasmodium vivax infections on pregnant women from the Westernmost region of the Brazilian Amazon
Grantee:Ricardo Tenreiro Estiveira de Ataide
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 09/53256-7 - Distress syndrome in a murine model associated to the severe malaria: a study of parasite-host interaction
Grantee:Sabrina Epiphanio
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/04755-3 - Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon
Grantee:Jamille Gregório Dombrowski
Support type: Scholarships in Brazil - Doctorate (Direct)