Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon

• Grant number: 12/04755-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2012
• End date: August 31, 2017
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Cláudio Romero Farias Marinho
• Grantee: Jamille Gregório Dombrowski
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria, AP.JP
• Associated scholarship(s): 16/13465-0 - Plasmodium vivax genomic analysis: identification of relapses and association with pregnancy adverse outcome in women from the Brazilian Amazon, BE.EP.DD

Abstract

Malaria is a major public health problem in different regions of the world, especially in developing countries, causing one million deaths annually, mainly children and pregnant women. Malaria in pregnancy is characterized by the presence of Plasmodium spp. in the peripheral blood or the placenta Malaria in Pregnancy may result in maternal anemia, intrauterine growth restriction (IUGR), low birth weight (LBW) and reduced fetal viability. Plasmodium vivax (P. vivax) is the dominant species of malaria outside of Africa, accounting for 25-40% of the cases of malaria worldwide. In Brazil, there is a predominance of infections by P. vivax, and about 95% of cases occur in the Amazon, with close to 500,000 new cases per year. Despite its high prevalence and its possible association with major complications during pregnancy, the effects of Plasmodium infections in pregnant women are still not fully understood. Both IUGR and LBW are strongly associated with neonatal mortality and morbidity, as well as inhibited growth and cognitive development in children with chronic diseases in adulthood. This project proposes to evaluate through both a retrospective and a prospective study, the magnitude of P. vivax and P. falciparum malaria in pregnant women in the Far-western Brazilian Amazon as well as estimating possible associations with LBW and IUGR. The knowledge of the impact of these infections on the placenta and on fetal development will bring an important contribution to the understanding of malaria during pregnancy, in addition to enabling new research directed at developing new diagnosis and treatment approaches. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PANDYA, YASH; MARTA, ALEXANDER; BARATEIRO, ANDRE; BANDEIRA, CARLA LETICIA; DOMBROWSKI, JAMILLE GREGORIO; COSTA, JOAO; FARIAS MARINHO, CLAUDIO ROMERO; PENHA-GONCALVES, CARLOS. TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria. Infection and Immunity, v. 89, n. 8, AUG 2021. (19/12068-5, 16/07030-0, 12/04755-3, 14/09964-5, 17/03939-7, 20/06747-4)

CAMPOS, MONICA C.; DOMBROWSKI, JAMILLE G.; PHELAN, JODY; MARINHO, CLAUDIO R. F.; HIBBERD, MARTIN; CLARK, TAANE G.; CAMPINO, SUSANA. Zika might not be acting alone: Using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil. PLoS One, v. 13, n. 8, AUG 15 2018. (12/04755-3, 16/07030-0)

REIS, ARAMYS S.; BARBOZA, RENATO; MURILLO, OSCAR; BARATEIRO, ANDRE; PEIXOTO, ERIKA P. M.; LIMA, FLAVIA A.; GOMES, VINICIUS M.; DOMBROWSKI, JAMILLE G.; LEAL, VINICIUS N. C.; ARAUJO, FRANCIELE; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. SCIENCE ADVANCES, v. 6, n. 10, MAR 2020. (14/09964-5, 15/23395-6, 14/20451-0, 17/03939-7, 11/19048-8, 17/05782-8, 13/16417-8, 16/07030-0, 12/16525-2, 12/04755-3, 15/50650-7, 18/20468-0, 13/00981-1, 11/17880-8, 15/06106-0)

ATAIDE, RICARDO; MURILLO, OSCAR; DOMBROWSKI, JAMILLE G.; SOUZA, RODRIGO M.; LIMA, FLAVIA A.; LIMA, GISELLE F. M. C.; HRISTOV, ANGELICA D.; VALLE, SUIANE C. N.; DI SANTI, SILVIA M.; EPIPHANIO, SABRINA; et al. Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta. PLoS Neglected Tropical Diseases, v. 9, n. 6, JUN 2015. (12/04755-3, 09/53256-7, 09/53889-0, 11/20921-8)

DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; et al. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5, MAY 2019. (14/17766-9, 18/20468-0, 12/04755-3, 13/21728-2, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 16/08204-2, 13/16417-8, 09/53889-0)

LIMA, FLAVIA AFONSO; BARATEIRO, ANDRE; DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; COSTA, DOUGLAS DE SOUSA; MURILLO, OSCAR; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Plasmodium falciparum infection dysregulates placental autophagy. PLoS One, v. 14, n. 12, DEC 5 2019. (17/03939-7, 17/05782-8, 13/16417-8, 12/04755-3, 16/07030-0, 15/06106-0, 13/00981-1, 18/20468-0)

DOMBROWSKI, JAMILLE G.; SOUZA, RODRIGO M.; CURRY, JONATHAN; HINTON, LAURA; SILVA, NATERCIA R. M.; GRIGNARD, LYNN; GONCALVES, LIGIA A.; GOMES, ANA RITA; EPIPHANIO, SABRINA; DRAKELEY, CHRIS; et al. G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon. Malaria Journal, v. 16, JUN 15 2017. (12/04755-3, 14/20451-0, 14/09964-5, 15/06106-0, 16/13465-0)

DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; MENDES SILVA, NATERCIA REGINA; BARATEIRO, ANDRE; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Malaria during pregnancy and newborn outcome in an unstable transmission area in Brazil: A population-based record linkage study. PLoS One, v. 13, n. 6, JUN 21 2018. (15/06106-0, 17/03939-7, 12/04755-3, 14/20451-0, 14/09964-5, 09/53889-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DOMBROWSKI, Jamille Gregório. Association between gestational malaria, intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.