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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats

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Author(s):
Spolidorio, Luis Carlos [1] ; Ramalho Lucas, Pablo Dallari [1] ; Steffens, Joao Paulo [1] ; Bueno da Silva, Henrique Aparecido [2] ; Euzebio Alves, Vanessa Tubero [2] ; Palomari Spolidorio, Denise M. [1] ; Holzhausen, Marinella [2]
Total Authors: 7
Affiliation:
[1] State Univ Sao Paulo, Dept Physiol & Pathol, Dent Sch Araraquara, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Periodont, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Periodontology; v. 85, n. 9, p. 1266-1274, SEP 2014.
Web of Science Citations: 6
Abstract

Background: Parstatin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activated receptor-1, with antiangiogenic properties. The purpose of this study is to evaluate the influence of synthetic parstatin on experimental periodontal disease and repair in rats. Methods: Ligature-induced periodontitis was established in rats and the influence of parstatin administration was assessed after 8 and 15 days for periodontal disease and 24 hours and 8 days after repair after ligature removal. Results: Parstatin administration significantly inhibited gingival myeloperoxidase activity, interleukin (IL)-1 beta, tumor necrosis factor-alpha, and IL-6 levels and led to suppression of macrophages and collagen degradation. At periodontal tissues under repair, parstatin increased the gingival levels of endostatin and decreased vascular endothelial growth factor expression and blood vessel number but did not influence histologic healing. In addition, the tomographic linear bone loss was significantly reduced at 15 days of periodontitis when the rats were treated with parstatin compared to their respective phosphate-buffered saline-treated controls. Conclusions: Parstatin suppresses the periodontal tissue breakdown followed by experimental periodontitis in rats and did not impair periodontal tissue repair, despite its antiangiogenic effect. Parstatin may represent a novel approach to modulate host response in chronic periodontal disease. (AU)

FAPESP's process: 10/16605-0 - Effect of periodontal therapy on protease activated receptor 2 (PAR-2) expression in chronic periodontitis patients.
Grantee:Marinella Holzhausen Caldeira
Support Opportunities: Regular Research Grants
FAPESP's process: 10/10715-9 - Evaluation of cytokines elaborated for platelet during the development of periodontal repair and disease in rats treated or not with antiplatelets drugs
Grantee:Luis Carlos Spolidorio
Support Opportunities: Regular Research Grants