Effects of dipyrone, meloxicam, or the combination on hemostasis in conscious dogs

Author(s)

Zanuzzo, Felipe S. ^[1] ; Teixeira-Neto, Francisco J. ^[2] ; Thomazini, Camila M. ^[3] ; Takahira, Regina K. ^[3] ; Conner, Bobbi ^[4] ; Diniz, Miriely S. ^[1]

Affiliation

^[1] Univ Estadual Paulista, UNESP, Fac Med, Dept Anesthesiol, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, BR-18618970 Botucatu, SP - Brazil

^[3] Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Vet Clin Sci, BR-18618970 Botucatu, SP - Brazil

^[4] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 - USA

• Document type: Journal article
• Source: JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE; v. 25, n. 4, p. 512-520, JUL-AUG 2015.
• Web of Science Citations: 4

Abstract

Objective - To compare the effects of dipyrone, meloxicam, and of the combination of these drugs on hemostasis in dogs. Design - Prospective, blinded, randomized crossover study. Setting - Research laboratory at a veterinary teaching hospital. Animals - Six adult dogs. Interventions - Animals received 4 intravenous treatments with 15-day washout intervals: control (physiological saline, 0.1 mL/kg), meloxicam (0.2 mg/kg), dipyrone (25 mg/kg), and dipyrone-meloxicam (25 and 0.2 mg/kg, respectively). A jugular catheter was placed for drug injection and for collecting samples for whole blood platelet aggregation (WBPA) and thromboelastometry assays at baseline, 1, 2, 3, 5, and 8 hours after treatment administration. The percent change from baseline of lag time and of the area under the curve (AUC) of impedance changes in response to collagen-induced platelet activation were recorded during WBPA. Thromboelastometry-derived parameters included clotting time, clot formation time, alpha-angle, and maximum clot firmness. The buccal mucosal bleeding time was evaluated by a blinded observer at baseline, 1, 3, and 5 hours after treatment injection. Measurements and Main Results - No significant changes in WBPA and thromboelastometry were recorded in the control treatment. Dipyrone significantly (P < 0.05) increased the lag time for 2 hours and decreased the AUC for 3 hours after injection. Meloxicam did not alter WBPA. Dipyrone-meloxicam significantly increased lag time for 2 hours and decreased the AUC for 5 hours after treatment injection. Experimental treatments did not differ from the control treatment for thromboelastometry and buccal mucosal bleeding time. Conclusions - While meloxicam does not alter hemostasis by the methods evaluated, dipyrone inhibits platelet aggregation for up to 3 hours. Meloxicam-dipyrone combination causes more prolonged inhibition of platelet function than dipyrone alone. Decreased platelet aggregation induced by dipyrone and dipyrone- meloxicam does not appear to impact the viscoelastic properties of the blood clot nor increase the risk of bleeding in dogs without preexisting hemostatic disorders. (AU)

• FAPESP's process: 12/09020-1 - Comparison of the effects of dipyrone, meloxicam and of the dipyrone/meloxicam combination on postoperative pain and on hemostasis in bitches submitted to ovariohysterectomy
• Grantee: Francisco José Teixeira Neto
• Support Opportunities: Regular Research Grants