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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Poor glycemic control impacts linear and non-linear dynamics of heart rate in DM type 2

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Author(s):
Bassi, Daniela [1] ; Arakelian, Vivian Maria [2] ; Mendes, Renata Goncalves [1] ; Rossi Caruso, Flavia Cristina [1] ; Bonjorno Junior, Jose Carlos [2] ; Lopes Zangrando, Katiany Thays [1] ; de Oliveira, Claudio Ricardo [3] ; Haus, Jacob [4, 5] ; Arena, Ross [6, 4] ; Borghi-Silva, Audrey [1]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Carlos UFSCar, Lab Cardiopulm, Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Dept Interunidades Bioengn, Sao Paulo - Brazil
[3] Univ Fed Sao Carlos UFSCar, Dept Med, Sao Carlos, SP - Brazil
[4] Univ Illinois, Integrat Physiol Lab, Coll Appl Hlth Sci, Chicago, IL - USA
[5] Univ Illinois, Dept Kinesiol & Nutr 6, Coll Appl Hlth Sci, Chicago, IL - USA
[6] Univ Illinois, Dept Phys Therapy, Coll Appl Hlth Sci, Chicago, IL - USA
Total Affiliations: 6
Document type: Journal article
Source: Revista Brasileira de Medicina do Esporte; v. 21, n. 4, p. 313-317, JUL-AUG 2015.
Web of Science Citations: 3
Abstract

INTRODUCTION: It is well known that type 2 diabetes mellitus (T2DM) produces cardiovascular autonomic neuropathy (CAN), which may affect the cardiac autonomic modulation. However, it is unclear whether the lack of glycemic control in T2DM without CAN could impact negatively on cardiac autonomic modulation. Objective: To evaluate the relationship between glycemic control and cardiac autonomic modulation in individuals with T2DM without CAN. Descriptive, prospective and cross sectional study.METHODS: Forty-nine patients with T2DM (51±7 years) were divided into two groups according to glycosylated hemoglobin (HbA1c): G1≤7% and G2>7.0%. Resting heart rate (HR) and RR interval (RRi) were obtained and calculated by linear (Mean iRR; Mean HR; rMSSD; STD RR; LF; HF; LF/HF, TINN and RR Tri,) and non-linear (SD1; SD2; DFα1; DFα2, Shannon entropy; ApEn; SampEn and CD) methods of heart rate variability (HRV). Insulin, HOMA-IR, fasting glucose and HbA1c were obtained by blood tests.RESULTS: G2 (HbA1c≤7%) showed lower values for the mean of iRR; STD RR; RR Tri, TINN, SD2, CD and higher mean HR when compared with G1 (HbA1c > 7%). Additionally, HbA1c correlated negatively with mean RRi (r=0.28, p=0.044); STD RR (r=0.33, p=0.017); RR Tri (r=-0.35, p=0.013), SD2 (r=-0.39, p=0.004) and positively with mean HR (r=0.28, p=0.045). Finally, fasting glucose correlated negatively with STD RR (r=-0.36, p=0.010); RR Tri (r=-0.36, p=0.010); TINN (r=-0.33, p=0.019) and SD2 (r=-0.42, p=0.002).CONCLUSION: We concluded that poor glycemic control is related to cardiac autonomic modulation indices in individuals with T2DM even if they do not present cardiovascular autonomic neuropathy. (AU)

FAPESP's process: 09/01842-0 - Analysis of central and peripheral muscle metabolism and adjustments on dynamic versus resistance exercise in coronary arterial disease patients: effects of resistance physical training program based on anaerobic threshold by different methodologies
Grantee:Audrey Borghi Silva
Support Opportunities: Research Grants - Young Investigators Grants