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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis

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Author(s):
Fernandes, V. [1] ; Osorio, F. L. [1, 2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Neurosci & Behav, BR-14048900 Sao Paulo - Brazil
[2] CNPq Translat Med, Technol Inst INCT, Rio De Janeiro - Brazil
Total Affiliations: 2
Document type: Review article
Source: EUROPEAN PSYCHIATRY; v. 30, n. 6, p. 756-764, SEP 2015.
Web of Science Citations: 15
Abstract

Background: Previous studies indicate a possible association between early emotional trauma (EET) and the development of anxiety disorders (ADs) in adult life. However, no previous studies have compiled the findings of such studies and analyzed their statistical significance. Therefore, the objective of this study was to conduct a systematic literature review and meta-analysis to determine possible associations between EET and three ADs (panic, generalized anxiety, and social anxiety disorders). Methods: A systematic search was conducted in PubMed, PsycInfo, and Scielo with no publication date limitations. A total of 2127 studies were found, 32 studies of which were selected for the systematic review and 13 studies of which were selected for the meta-analysis. Results: High prevalence rates of different EETs were observed among the individuals with ADs (median: 18%-45%). The results of the meta-analysis indicated that individuals with EETs were 1.9- to 3.6-fold more likely to develop ADs compared with a control group of healthy individuals. Emotional traumas were the main risk factor for social anxiety disorder. However, no specific associations were found for the other ADs. Conclusions: EET is a risk factor for ADs, underscoring the importance of preventive measures to combat the development of these disorders. Moreover, the identification of EETs among patients with ADs is essential for implementing remedial measures to minimize the impact and damage arising from this association by decreasing the risk and severity of symptoms and to improve the response rate to treatment of ADs. (C) 2015 Elsevier Masson SAS. All rights reserved. (AU)

FAPESP's process: 12/02260-7 - Early emotional traumas, psychiatric disorders and recognition of facial expressions: adaptation of instruments and clinical studies involving the prevalence and association of variables
Grantee:Flávia de Lima Osório
Support Opportunities: Regular Research Grants