| Full text | |
| Author(s): |
Slavov, S. N.
[1]
;
Vilar, F. C.
[2]
;
Wagatsuma, V. M. D.
[3]
;
Santana, R. C.
[2]
;
Machado, A. A.
[2]
;
da Fonseca, B. A. L.
[2]
;
Kashima, S.
[4, 1]
;
Covas, D. T.
[1, 5]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Hemoctr Ribeirao Preto, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Div Molestias Infecciosas & Trop, Dept Clin Med, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Lab Hematol Expt, Dept Clin Med, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Dept Analises Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Dept Cli Med, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 48, n. 9, p. 777-781, SEP 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
The emergence of ganciclovir (GCV) resistance during the treatment of human cytomegalovirus (HCMV) infection is a serious clinical challenge, and is associated with high morbidity and mortality. In this case report, we describe the emergence of two consecutive mutations (A594V and L595W) related to GCV resistance in a patient with HCMV retinitis and long-term HIV progression after approximately 240 days of GCV use. Following the diagnosis of retinitis, the introduction of GCV did not result in viral load reduction. The detected mutations appeared late in the treatment, and we propose that other factors (high initial HCMV load, previous GCV exposure, low CD4+ cell count), in addition to the presence of resistance mutations, may have contributed to the treatment failure of HCMV infection in this patient. (AU) | |
| FAPESP's process: | 09/16623-1 - Molecular pathogenesis and clinical consequences of the infections caused by the Human Parvovirus B19 and Human Cytomegalovirus among patients with hemaglobinopathies and haemophilia |
| Grantee: | Svetoslav Nanev Slavov |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |