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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dinor Casearin X, a New Cytotoxic Clerodane Diterpene from Casearia sylvestris

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Bou, Diego D. [1] ; dos Santos, Augusto L. [1] ; Figueiredo, Carlos R. [2] ; Farias, Camyla F. [2] ; Matsuo, Alisson L. [2] ; Kitamura, Rodrigo O. S. [3] ; Gimenes, Leila [3] ; Lago, Joao H. G. [1] ; Sartorelli, Patricia [1]
Total Authors: 9
[1] Univ Fed Sao Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Micro Imuno & Parasitol, Disciplina Biol Celular, BR-04021001 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Carlos UFSCar, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 26, n. 8, p. 1725-1729, AUG 2015.
Web of Science Citations: 3

A new clerodane-type diterpene, named dinor casearin X, and four known casearins (A, B, G and J) were isolated from leaves of Casearia sylvestris (Salicaceae). These compounds were evaluated for cytotoxic activity against five human cancer cell lines (A2058, HL-60, HCT, MCF-7 and HeLa) as well as against a murine melanoma cell line (B16F10-Nex2). Among these compounds, dinor casearin X exhibited the highest cytotoxic activity against HL-60 cells with IC50 of 0.51 +/- 0.11 mu g mL(-1), whereas casearin A exhibited the highest cytotoxic activity against HCT cells (IC50 1.84 +/- 0.14 mu g mL(-1)). (AU)

FAPESP's process: 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species
Grantee:João Henrique Ghilardi Lago
Support type: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 13/16320-4 - Prospection of anti-parasitic and anti-tumor metabolites from plant species of the Atlantic Forest
Grantee:Patricia Sartorelli
Support type: Regular Research Grants