| Full text | |
| Author(s): |
Bou, Diego D.
[1]
;
dos Santos, Augusto L.
[1]
;
Figueiredo, Carlos R.
[2]
;
Farias, Camyla F.
[2]
;
Matsuo, Alisson L.
[2]
;
Kitamura, Rodrigo O. S.
[3]
;
Gimenes, Leila
[3]
;
Lago, Joao H. G.
[1]
;
Sartorelli, Patricia
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Fed Sao Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Micro Imuno & Parasitol, Disciplina Biol Celular, BR-04021001 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Carlos UFSCar, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 26, n. 8, p. 1725-1729, AUG 2015. |
| Web of Science Citations: | 3 |
| Abstract | |
A new clerodane-type diterpene, named dinor casearin X, and four known casearins (A, B, G and J) were isolated from leaves of Casearia sylvestris (Salicaceae). These compounds were evaluated for cytotoxic activity against five human cancer cell lines (A2058, HL-60, HCT, MCF-7 and HeLa) as well as against a murine melanoma cell line (B16F10-Nex2). Among these compounds, dinor casearin X exhibited the highest cytotoxic activity against HL-60 cells with IC50 of 0.51 +/- 0.11 mu g mL(-1), whereas casearin A exhibited the highest cytotoxic activity against HCT cells (IC50 1.84 +/- 0.14 mu g mL(-1)). (AU) | |
| FAPESP's process: | 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species |
| Grantee: | João Henrique Ghilardi Lago |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |
| FAPESP's process: | 13/16320-4 - Prospection of anti-parasitic and anti-tumor metabolites from plant species of the Atlantic Forest |
| Grantee: | Patricia Sartorelli |
| Support Opportunities: | Regular Research Grants |