Dinor Casearin X, a New Cytotoxic Clerodane Diterpene from Casearia sylvestris

Author(s)

Bou, Diego D. ^[1] ; dos Santos, Augusto L. ^[1] ; Figueiredo, Carlos R. ^[2] ; Farias, Camyla F. ^[2] ; Matsuo, Alisson L. ^[2] ; Kitamura, Rodrigo O. S. ^[3] ; Gimenes, Leila ^[3] ; Lago, Joao H. G. ^[1] ; Sartorelli, Patricia ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Micro Imuno & Parasitol, Disciplina Biol Celular, BR-04021001 Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Carlos UFSCar, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 26, n. 8, p. 1725-1729, AUG 2015.
• Web of Science Citations: 3

Abstract

A new clerodane-type diterpene, named dinor casearin X, and four known casearins (A, B, G and J) were isolated from leaves of Casearia sylvestris (Salicaceae). These compounds were evaluated for cytotoxic activity against five human cancer cell lines (A2058, HL-60, HCT, MCF-7 and HeLa) as well as against a murine melanoma cell line (B16F10-Nex2). Among these compounds, dinor casearin X exhibited the highest cytotoxic activity against HL-60 cells with IC50 of 0.51 +/- 0.11 mu g mL(-1), whereas casearin A exhibited the highest cytotoxic activity against HCT cells (IC50 1.84 +/- 0.14 mu g mL(-1)). (AU)

• FAPESP's process: 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species
• Grantee: João Henrique Ghilardi Lago
• Support type: BIOTA-FAPESP Program - Regular Research Grants
• FAPESP's process: 13/16320-4 - Prospection of anti-parasitic and anti-tumor metabolites from plant species of the Atlantic Forest
• Grantee: Patricia Sartorelli
• Support type: Regular Research Grants