Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease

Author(s)

Ayo, Christiane Maria ^[1] ; de Oliveira, Amanda Priscila ^[1] ; da Silveira Camargo, Ana Vitoria ^[1] ; Brandao de Mattos, Cinara Cassia ^[1] ; Bestetti, Reinaldo Bulgarelli ^[2] ; de Mattos, Luiz Carlos ^[1]

Affiliation

^[1] Fac Med Sao Jose Rio Preto FAMERP, Dept Biol Mol, Lab Imunogenet, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[2] Fac Med Sao Jose Rio Preto FAMERP, Dept Cardiol Cirurgia Cardiovasc, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: Clinical Infectious Diseases; v. 61, n. 8, p. 1310-1313, OCT 15 2015.
• Web of Science Citations: 10

Abstract

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD. (AU)

• FAPESP's process: 11/08075-4 - Immunogenetic markers related to Chagas disease
• Grantee: Luiz Carlos de Mattos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/25650-8 - Class II HLA genes (DRB1 and DQB1) as risck factors for ocular toxoplasmosis
• Grantee: Luiz Carlos de Mattos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/06580-9 - KIR genes, their HLA ligands and MICA gene polymorphism in ocular toxoplasmosis and in digestive form of Chagas disease
• Grantee: Christiane Maria Ayo
• Support Opportunities: Scholarships in Brazil - Doctorate