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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease

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Author(s):
Ayo, Christiane Maria [1] ; de Oliveira, Amanda Priscila [1] ; da Silveira Camargo, Ana Vitoria [1] ; Brandao de Mattos, Cinara Cassia [1] ; Bestetti, Reinaldo Bulgarelli [2] ; de Mattos, Luiz Carlos [1]
Total Authors: 6
Affiliation:
[1] Fac Med Sao Jose Rio Preto FAMERP, Dept Biol Mol, Lab Imunogenet, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Fac Med Sao Jose Rio Preto FAMERP, Dept Cardiol Cirurgia Cardiovasc, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Clinical Infectious Diseases; v. 61, n. 8, p. 1310-1313, OCT 15 2015.
Web of Science Citations: 10
Abstract

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD. (AU)

FAPESP's process: 11/08075-4 - Immunogenetic markers related to Chagas disease
Grantee:Luiz Carlos de Mattos
Support Opportunities: Regular Research Grants
FAPESP's process: 13/25650-8 - Class II HLA genes (DRB1 and DQB1) as risck factors for ocular toxoplasmosis
Grantee:Luiz Carlos de Mattos
Support Opportunities: Regular Research Grants
FAPESP's process: 13/06580-9 - KIR genes, their HLA ligands and MICA gene polymorphism in ocular toxoplasmosis and in digestive form of Chagas disease
Grantee:Christiane Maria Ayo
Support Opportunities: Scholarships in Brazil - Doctorate