Inflammatory cytokine kinetics to single bouts of acute moderate and intense aerobic exercise in women with active and inactive systemic lupus erythematosus

Author(s):Show less -

Perandini, L. A. ^[1] ; Sales-de-Oliveira, D. ^[1] ; Mello, V, S. B. ; Camara, N. O. ^[2] ; Benatti, F. B. ^{[3, 4]} ; Lima, F. R. ^[3] ; Borba, E. ^[3] ; Bonfa, E. ^[3] ; Roschel, H. ^{[3, 4]} ; Sa-Pinto, A. L. ^{[3, 4]} ; Gualano, B. ^{[3, 4]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Div Rheumatol, BR-01246903 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, BR-01246903 Sao Paulo, SP - Brazil

^[3] Mello, S. B., V, Univ Sao Paulo, Sch Med, Div Rheumatol, BR-01246903 Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sport, BR-01246903 Sao Paulo, SP - Brazil

• Document type: Review article
• Source: EXERCISE IMMUNOLOGY REVIEW; v. 21, p. 174-185, 2015.
• Web of Science Citations: 13

Abstract

Objectives: The aim of this study was to evaluate changes in the cytokines INF-gamma, IL-10, IL-6, TNF-alpha and soluble TNF receptors (sTNFR1 and sTNFR2) in response to single bouts of acute moderate and intense exercise in systemic lupus erythematosus women with active (SLEACTIVE) and inactive (SLEINACTIVE) disease. Methods: Twelve SLEINACTIVE women (age: 35.3 +/- 5.7 yrs: 25.6 +/- 3.4 kg/m(2)), eleven SLEINACTIVE women (age: 30.4 +/- 4.5 yrs; 26.1 +/- 4.8 kg/m(2)), and 10 age- and BMI-matched healthy control women (HC) performed 30 minutes of acute moderate (similar to 50% of VO(2)peak) and intense (similar to 70% of VO(2)peak) exercise bout. Cytokines and,soluble TNF receptors were assessed at baseline, immediately after; every 30 minutes up to three howls, and 24 hours after both acute exercise bouts. Results: In response to acute moderate exercise, cytokines and soluble TNF receptors levels remained unchanged in all groups (P>0.05), except for a reduction in IL-6 levels in the SLEACTIVE group at the 60th and 180th minutes of recovery (P<0.05), and a reduction in sTNFR1 levels in the He group at the 90th, 120th, 150th, 180th minutes of recovery (P<0.05). The SLEINACTIVE group showed higher levels of TNF-alpha, sTNFR1, and sTNFR2 at all time points when compared with the HC group (P<0.05). Also, the SLEACTIVE group showed higher levels of IL-6 at the 60th minute of recovery (P<0.05) when compared with the HC group. After intense exercise, sTNFR1 levels were reduced at the 150th (P=0.041) and 180th (P=0.034) minutes of recovery in the group. whereas the other cytokines and sTNFR2 levels remained unchanged (P>0.05). hi the He group, IL-10, TNF-alpha, sTNFR1, and sTNFR2 levels did not change, whilst INF-gamma levels decreased (P=0.05) and IL-6 levels increased immediately after the exercise (P=0.028), returning to baseline levels 24 hours later (P > 0.05). When compared with the HC group, the SLEINACTIVE, group showed higher levels of TNF-alpha and sTNFR2 in all time points, and higher levels of sTNFR1 at the end of exercise and at the 30th minute of recovery (P<0.05). The SLEACTIVE group also showed higher levels of TNF-alpha at all time points when compared with the HC group (P<0.05), (except after 90 min, 120 min and 24 hours of recovery) (P>0.05). Importantly, the levels of all cytokine and soluble TNF receptors returned to baseline 24 hours after the end of acute exercise, irrespective of its intensity in all three groups (P>0.05). Conclusion: This study demonstrated that both the single bouts of acute moderate and intense exercise induced mild and transient changes in cytokine levels in both SLEINACTIVE and SLEACTIVE women, providing novel evidence that acute aerobic execise does not trigger inflammation in patients with this disease. (AU)

• FAPESP's process: 11/24093-2 - The effects of endurance exercise on the inflammatory profile and insulin sensitivity in women with systemic lupus erithematosus
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Support Opportunities: Regular Research Grants