Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile

Author(s)

da Silva, Emerson Rodrigo ^{[1, 2]} ; Alves, Wendel Andrade ^[1] ; Castelletto, Valeria ^[2] ; Reza, Mehedi ^[3] ; Ruokolainen, Janne ^[3] ; Hussain, Rohanah ^[4] ; Hamley, Ian William ^[2]

Affiliation

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre - Brazil

^[2] Univ Reading, Dept Chem, Whiteknights Reading RG6 6AD, Berks - England

^[3] Aalto Univ, Sch Sci, Dept Appl Phys, FIN-00076 Aalto - Finland

^[4] Diamond Light Source Ltd, Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon - England

• Document type: Journal article
• Source: CHEMICAL COMMUNICATIONS; v. 51, n. 58, p. 11634-11637, 2015.
• Web of Science Citations: 22

Abstract

The self-assembly of peptide nanotubes formed by an L-glutamic acid-based bolaamphiphile is shown to proceed via a remarkable mechanism where the peptide conformation changes from beta-sheet to unordered. The kinetics of this process are elucidated via X-ray scattering and UV circular dichroism methods. The reverse transition from ``unordered'' to beta-sheet structures is triggered by UV radiation. (AU)

• FAPESP's process: 14/03514-8 - Structural investigations on model-systems based on amphiphilic peptides
• Grantee: Emerson Rodrigo da Silva
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 13/12997-0 - Hierarchical self-organization of peptide amphiphiles: fundamental mechanisms and potential applications
• Grantee: Wendel Andrade Alves
• Support Opportunities: Regular Research Grants