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Hierarchical self-organization of peptide amphiphiles: fundamental mechanisms and potential applications

Abstract

We propose the synthesis and characterization of new peptide nanostructures obtained from self-assembling reactions. Inedited peptide sequences of types bola-amphiphile and lipopeptide will be prepared. The choice for these classes relies on the rich polymorphism of mesophases they are able to form and on their ability to establish biointerfaces through molecular recognition, increasing their range of applications significantly. We will evaluate the formation of these systems and the kind of interactions appearing in their construction. Small- and wide-angle scattering techniques (SAXS and WAXS) will be used to probe structural aspects in order to provide insights on the physicochemical mechanisms implied in the self-assembly. After determining the optimal conditions for obtaining the arrays, their respective phase diagrams will raised. To achieve this, techniques providing complementary information in both direct and reciprocal space will be used. Besides data on structure and morphology, these techniques will bring parameters on elastic and thermodynamic properties. This information, combined with data from in silico experiments, will contribute for elucidating basic mechanisms involved in the building of the nanostructures. In following, structural changes will be evaluated in the peptides by varying the amino acid residues. The goal is to obtain different supramolecular organizations with potential applications in detection architectures. Furthermore, this kind of hierarchical assembly could be followed in situ by using SAXS techniques, as it was previously demonstrated. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
H<sub>2</sub>O en el nanotubo 
H<sub>2</sub>O in nanotubes 

Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KOGIKOSKI, JR., SERGIO; LIBERATO, MICHELLE S.; FACTORI, IRINA M.; DA SILVA, EMERSON R.; OLIVEIRA, CRISTIANO L. P.; ANDO, ROMULO A.; ALVES, WENDEL A. Polycaprolactone-Polyaniline Blend: Effects of the Addition of Cysteine on the Structural and Molecular Properties. Journal of Physical Chemistry C, v. 121, n. 1, p. 863-877, JAN 12 2017. Web of Science Citations: 8.
ANDRADE-FILHO, T.; MARTINS, TIAGO CARVALHO; FERREIRA, FABIO FURLAN; ALVES, WENDEL ANDRADE; ROCHA, ALEXANDRE REILY. Water-driven stabilization of diphenylalanine nanotube structures. THEORETICAL CHEMISTRY ACCOUNTS, v. 135, n. 8 JUL 11 2016. Web of Science Citations: 13.
SOUZA, JULIANA S.; PINHEIRO, MAURICIO V. B.; KRAMBROCK, KLAUS; ALVES, WENDEL A. Dye Degradation Mechanisms Using Nitrogen Doped and Copper(II) Phthalocyanine Tetracarboxylate Sensitized Titanate and TiO2 Nanotubes. Journal of Physical Chemistry C, v. 120, n. 21, p. 11561-11571, JUN 2 2016. Web of Science Citations: 6.
KOGIKOSKI, JR., S.; SOUSA, C. P.; LIBERATO, M. S.; ANDRADE-FILHO, T.; PRIETO, T.; FERREIRA, F. F.; ROCHA, A. R.; GUHA, S.; ALVES, W. A. Multifunctional biosensors based on peptide-polyelectrolyte conjugates. Physical Chemistry Chemical Physics, v. 18, n. 4, p. 3223-3233, JAN 28 2016. Web of Science Citations: 11.
LIBERATO, M. S.; KOGIKOSKI, JR., S.; DA SILVA, E. R.; DE ARAUJO, D. R.; GUHA, S.; ALVES, W. A. Polycaprolactone fibers with self-assembled peptide micro/nanotubes: a practical route towards enhanced mechanical strength and drug delivery applications. JOURNAL OF MATERIALS CHEMISTRY B, v. 4, n. 8, p. 1405-1413, 2016. Web of Science Citations: 15.
SOUZA, J. S.; CARVALHO, JR., W. M.; SOUZA, F. L.; PONCE-DE-LEON, C.; BAVYKIN, D. V.; ALVES, W. A. Multihierarchical electrodes based on titanate nanotubes and zinc oxide nanorods for photoelectrochemical water splitting. JOURNAL OF MATERIALS CHEMISTRY A, v. 4, n. 3, p. 944-952, 2016. Web of Science Citations: 7.
DA SILVA, EMERSON RODRIGO; WALTER, MERLIN NATHANIEL MARK; REZA, MEHEDI; CASTELLETTO, VALERIA; RUOKOLAINEN, JANNE; CONNON, CHE JOHN; ALVES, WENDEL ANDRADE; HAMLEY, IAN WILLIAM. Self-Assembled Arginine-Capped Peptide Bolaamphiphile Nanosheets for Cell Culture and Controlled Wettability Surfaces. Biomacromolecules, v. 16, n. 10, p. 3180-3190, OCT 2015. Web of Science Citations: 23.
KHANRA, SOMA; CIPRIANO, THIAGO; LAM, THOMAS; WHITE, TOMMI A.; FILETI, EUDES E.; ALVES, WENDEL A.; GUHA, SUCHISMITA. Self-Assembled Peptide-Polyfluorene Nanocomposites for Biodegradable Organic Electronics. ADVANCED MATERIALS INTERFACES, v. 2, n. 14 SEP 22 2015. Web of Science Citations: 16.
DECANDIO, CARLA C.; SILVA, EMERSON R.; HAMLEY, IAN W.; CASTELLETTO, VALERIA; LIBERATO, MICHELLE S.; OLIVEIRA, JR., VANI X.; OLIVEIRA, CRISTIANO L. P.; ALVES, WENDEL A. Self-Assembly of a Designed Alternating Arginine/Phenylalanine Oligopeptide. Langmuir, v. 31, n. 15, p. 4513-4523, APR 21 2015. Web of Science Citations: 21.
SOUSA, CAMILA P.; COUTINHO-NETO, MAURICIO D.; LIBERATO, MICHELLE S.; KUBOTA, LAURO T.; ALVES, WENDEL A. Self-Assembly of Peptide Nanostructures onto an Electrode Surface for Nonenzymatic Oxygen Sensing. Journal of Physical Chemistry C, v. 119, n. 2, p. 1038-1046, JAN 15 2015. Web of Science Citations: 15.
DA SILVA, EMERSON RODRIGO; ALVES, WENDEL ANDRADE; CASTELLETTO, VALERIA; REZA, MEHEDI; RUOKOLAINEN, JANNE; HUSSAIN, ROHANAH; HAMLEY, IAN WILLIAM. Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile. CHEMICAL COMMUNICATIONS, v. 51, n. 58, p. 11634-11637, 2015. Web of Science Citations: 22.
CIPRIANO, THIAGO; KNOTTS, GRANT; LAUDARI, AMRIT; BIANCHI, ROBERTA C.; ALVES, WENDEL A.; GUHA, SUCHISMITA. Bioinspired Peptide Nanostructures for Organic Field-Effect Transistors. ACS APPLIED MATERIALS & INTERFACES, v. 6, n. 23, p. 21408-21415, DEC 20 2014. Web of Science Citations: 19.
SOUZA, JULIANA S.; KRAMBROCK, KLAUS; PINHEIRO, MAURICIO V. B.; ANDO, ROMULO A.; GUHA, SUCHISMITA; ALVES, WENDEL A. Visible-light photocatalytic activity of NH4NO3 ion-exchanged nitrogen-doped titanate and TiO2 nanotubes. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, v. 394, p. 48-56, NOV 15 2014. Web of Science Citations: 9.
BIANCHI, ROBERTA C.; DA SILVA, EMERSON RODRIGO; DALL'ANTONIA, LUIZ H.; FERREIRA, FABIO FURLAN; ALVES, WENDEL ANDRADE. A Nonenzymatic Biosensor Based on Gold Electrodes Modified with Peptide Self-Assemblies for Detecting Ammonia and Urea Oxidation. Langmuir, v. 30, n. 38, p. 11464-11473, SEP 30 2014. Web of Science Citations: 23.
SOUZA, MARCIA I.; SILVA, EMERSON R.; JAQUES, YGOR M.; FERREIRA, FABIO F.; FILETI, EUDES E.; ALVES, WENDEL A. The role of water and structure on the generation of reactive oxygen species in peptide/hypericin complexes. JOURNAL OF PEPTIDE SCIENCE, v. 20, n. 7, SI, p. 554-562, JUL 2014. Web of Science Citations: 16.

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