| Grant number: | 13/12674-6 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | December 01, 2013 |
| End date: | June 09, 2016 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Physical-Chemistry |
| Principal Investigator: | Wendel Andrade Alves |
| Grantee: | Emerson Rodrigo da Silva |
| Host Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil |
| Associated scholarship(s): | 14/03514-8 - Structural investigations on model-systems based on amphiphilic peptides, BE.EP.PD |
Abstract We propose the synthesis and characterization of new peptide nanostructures obtained from self-assembly reactions. Inedited peptide sequences of bola-amphiphile and lipopeptide type will be prepared. The choice of these classes relies on the rich polymorphism of mesophases they are able to form and on their ability to establish biointerfaces through molecular recognition, increasing their range of applications significantly. We intend to evaluate the formation of these systems and contribute to elucidate the interactions appearing in their construction. Small- and wide-angle scattering techniques (SAXS and WAXS) will be used to probe structural aspects in order to provide insights on the physicochemical mechanisms implied in the self-assembly. After determining the optimal conditions for obtaining the arrays, their respective phase diagrams will be raised. To achieve this, techniques providing complementary information in both direct and reciprocal space will be used. Besides data on structure and morphology, these techniques will supply parameters on elastic and thermodynamic properties. This information, combined with data from in silico experiments performed by collaborators, will contribute for elucidating basic mechanisms involved in the building of the nanostructures. In following, structural changes will be evaluated in the peptides by varying the amino acid residues. The goal is to obtain different supramolecular organizations with potential applications in detection architectures. Furthermore, this hierarchical assembly could be followed in situ by using SAXS techniques, as previously demonstrated. (AU) | |
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