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Structural investigation of lipid and amphiphilic peptides via Langmuir and Langmuir-Blodgett films

Grant number: 20/02192-8
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): February 01, 2021
Effective date (End): January 31, 2022
Field of knowledge:Biological Sciences - Biophysics - Biophysics of Processes and Systems
Principal researcher:Wendel Andrade Alves
Grantee:Barbara Bianca Gerbelli
Supervisor abroad: Ian William Hamley
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Research place: University of Reading, England  
Associated to the scholarship:18/05888-3 - Biosensors based on amphiphilic peptides for detection and diagnosis of diseases, BP.PD

Abstract

We propose the synthesis and characterization of new lipopeptide as functional models of the enzyme acetylcholinesterase (AChE) nanostructures obtained from self-assembly and the AChE, which is usually used in pesticide biosensors. For this study, the control of molecular architectures will be explored by using the Langmuir and Langmuir-Blodgett techniques, employing mixtures of unsaturated lipids (such as lecithin/DPPC) and lipopeptides compounds. The choice for these classes relies on the rich polymorphism of mesophases that they can form and, on their ability, to establish bio-interfaces through molecular recognition, which increases their application significantly. Scattering techniques (X-rays and neutrons) will be used to probe structural aspects and provide insights into the mechanisms involved in the self-assembly. Techniques providing complementary information in both direct space will be used, as spectroscopy and microscopy. The combination of these techniques will allow us to correlate the physicochemical mechanisms involved in the building of the nanostructures. In following, structural changes will be evaluated in the peptides by varying the amino acid residues. The goal is to obtain different supramolecular organizations with potential applications as pesticide biosensors. (AU)

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