Effects of the long-term administration of alendronate on the mechanical properties of the basal bone and on osseointegration

Author(s)

Verzola, Mario Henrique A. ^[1] ; Frizzera, Fausto ^{[1, 2]} ; de Oliveira, Guilherme J. P. L. ^[1] ; Pereira, Rosa M. R. ^[3] ; Rodrigues-Filho, Ubirajara P. ^[4] ; Nonaka, Keico Okino ^[5] ; Orrico, Silvana R. P. ^[1]

Affiliation

^[1] Univ Estadual Paulista, Araraquara Dent Sch, FOAr UNESP, Araraquara - Brazil

^[2] FAESA, Sch Dent, Integrated Coll Espirito Santentes, Vitoria - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Rheumatol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Chem, Sao Carlos, SP - Brazil

^[5] Univ Fed Sao Carlos, Exercise Physiol Lab, BR-13560 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Clinical Oral Implants Research; v. 26, n. 12, p. 1466-1475, DEC 2015.
• Web of Science Citations: 4

Abstract

Objective To evaluate the effect of the long-term administration of alendronate on the mechanical properties of the basal bone and on osseointegration. Material and methods One hundred and sixty female rats were randomly allocated into two equally sized groups: the control (CTL) group, which received the subcutaneous administration of saline solution, and the alendronate (ALD) group, which received the subcutaneous administration of alendronate (1mg/kg/week). After 120days of these therapies, one implant was placed in each rat tibia. Ten animals in each group were euthanized at 5, 10, 15, 20, 25, 30, 45, or 60days after surgery. The tibias with implants evaluated regarding the removal torque, bone-implant contact (BIC), the bone area fraction occupancy (BAFO), and Ca/P ratio. The femurs were evaluated regarding bone mineral density (BMD) and using mechanical tests to evaluate the maximal force of fracture, stiffness, and tenacity. Results The ALD group presented statistically significant higher BMD (all periods except 15days), maximal force of fracture (at 20, 30, and 45days), tenacity (at 10, 20, 30, and 45days), stiffness (45days), removal torque (at 20, 25 and 30 days), BIC (at 20 and 60days), and BAFO (at 20, 30, and 45days) than the CTL group. No differences were found between the groups regarding the Ca/P ratio. Conclusion Previous long-term therapy with alendronate caused an increase in the BMD, maximal force of fracture of the bone without changing the inorganic composition and elastic deformability of this tissue. Furthermore, the ALD therapy enhanced osseointegration. (AU)

• FAPESP's process: 12/16939-1 - Evaluation of bone repair and mineralization in animals submitted to alendronate treatment
• Grantee: Silvana Regina Perez Orrico
• Support Opportunities: Regular Research Grants