Cyclodextrin-Based Delivery Systems for Arthritic Diseases: From Development to Experimental Therapeutics

Author(s)

Monteiro Nascimento, Monica Helena ^[1] ; Santos Akkari, Alessandra Cristina ^[1] ; Freitas Mariano, Kelly Cristina ^[1] ; Kimus Braz, Antonio Sergio ^[1] ; Lombello, Christiane Bertachini ^[2] ; de Araujo, Daniele Ribeiro ^[1]

Affiliation

^[1] ABC Fed Univ, Human & Nat Sci Ctr, BR-09021058 Santo Andre, SP - Brazil

^[2] ABC Fed Univ, Engn Modelling & Appl Social Sci Ctr, BR-09021058 Santo Andre, SP - Brazil

• Document type: Journal article
• Source: CURRENT PHARMACEUTICAL DESIGN; v. 21, n. 33, p. 4907-4916, 2015.
• Web of Science Citations: 3

Abstract

Arthritics diseases, such as rheumatoid arthritis and osteoarthritis are chronic inflammatory and one of the most prevalent health conditions that cause disability (pain and functional limitation of joints). Despite the research advances, the treatment of those pathological conditions remains ineffective, since the pharmacological therapy is palliative, reducing only the symptoms and, in some cases, the chronic progression of the disease. In this context, the development of new formulations for controlled release would be interesting for reducing the number of injections and would also increase the patient compliance. In this article, we present a review of the cyclodextrin (CD)-based delivery systems focusing from conventional guest-host inclusion complexes and CD-polysulphates, until supramolecular architectures such as drug-CD-polymers conjugates, pseudorotaxanes, hydrogels as well as double-carrier systems and other systems. In particular, this article focuses the main CD-based delivery systems described in the literature emphasizing their possible administration by intra-articular route on the treatment of arthritic diseases, concentrating on their development and also performance as in vivo experimental therapeutic systems. (AU)

• FAPESP's process: 14/12653-1 - Development of chitosan-tripolyphosphate nanoparticles dispersed in thermoreversible hydrogels for intra-articular delivery of naproxen
• Grantee: Kelli Cristina Freitas Mariano
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 14/26200-9 - Nanostructured hybrid systems for modified release of antiinflammatpry drugs: development and pharmacological evaluation
• Grantee: Daniele Ribeiro de Araujo
• Support Opportunities: Regular Research Grants