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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Salivary markers in patients with chronic renal failure

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Author(s):
Pallos, Debora [1, 2] ; Leao, Mariella V. P. [3, 4] ; Togeiro, Fernanda C. F. B. [2] ; Alegre, Larissa [2] ; Ricardo, Lucilene Hernandes [5] ; Perozini, Caroline [2] ; Ruivo, Gilson Fernandes [6]
Total Authors: 7
Affiliation:
[1] Univ Santo Amaro, Implantol Dept, Sao Paulo - Brazil
[2] Univ Taubate, Dept Periodont, Taubate, SP - Brazil
[3] Univ Taubate, Basic Biosci Inst, Taubate, SP - Brazil
[4] Univ Taubate, Biosci & Oral Diag, Taubate, SP - Brazil
[5] Private Off, Pindamonhangaba - Brazil
[6] Univ Taubate, Dept Med, Taubate, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 60, n. 12, p. 1784-1788, DEC 2015.
Web of Science Citations: 12
Abstract

Introduction: Chronic renal failure (CRF) is a progressive loss of renal function over a period of months or years. The major function of the kidneys is the removal of metabolic waste products, electrolytes and water. When this function is impaired, systemic changes, oral complications and alterations in salivary composition may occur. Objective: This study aimed to compare the levels of immunological and inflammatory components in the saliva samples from patients that undergo to hemodialysis treatment (HD), without HD and control. Design: This study evaluated IgA, IgG, C reactive protein (CRP) and nitric oxide (NO) in saliva samples from 119 patients, who were divided into the control group (C), chronic renal failure (CRF) patient group and CRF patients on hemodialysis treatment (HD) group. IgA and IgG levels were analyzed by ELISA. Nitric oxide levels were determined indirectly by the nitrite concentration using Griess reagent; CRP by agglutination tests; and total proteins, by Bradford assay. Results: The HD group showed significantly higher levels of IgG, IgA and CRP compared with the control and CRF groups. The CRF group presented the same amounts of IgG, IgA and CRP as the C group but significantly higher levels of NO similar to the HD group. Conclusion: Renal disease, particularly hemodialysis treatment during renal disease, seems to alter salivary immunological and inflammatory components. Thus, analyzing the levels of IgA, IgG, NO and CRP in saliva may be beneficial for monitoring renal disease. (C) 2015 Elsevier Ltd. All rights reserved. (AU)