Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise

Author(s)

Beck, Wladimir Rafael ^[1] ; Botezelli, Jose Diego ^[2] ; Pauli, Jose Rodrigo ^[2] ; Ropelle, Eduardo Rochete ^[2] ; Gobatto, Claudio Alexandre ^[1]

Affiliation

^[1] Univ Estadual Campinas, Lab Appl Sport Physiol, Sch Appl Sci, Dept Sport Sci, BR-13484350 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Lab Mol Biol Exercise, Sch Appl Sci, Dept Sport Sci, BR-13484350 Sao Paulo - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 5, DEC 16 2015.
• Web of Science Citations: 5

Abstract

It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation. (AU)

• FAPESP's process: 09/08535-5 - Standardization and validity of aerobic and anaerobic tests in field and laboratory, using free, tethered and half-tethered running, in endurance and sprint runners
• Grantee: Claudio Alexandre Gobatto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/20501-1 - Molecular responses of continuous and intermitent swimming and of exogenous melatonin in rats: cell signalizers of the intermediary metabolism and from the inflammatory and oxidative stress pathways
• Grantee: Claudio Alexandre Gobatto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/13226-1 - Ergogenic response of melatonin during the nadir and acrophase of spontaneous activity: consequences on IKK/Nf-kB via
• Grantee: Wladimir Rafael Beck
• Support Opportunities: Scholarships in Brazil - Doctorate