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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optimized Diagnostic Assays Based on Redox Tagged Bioreceptive Interfaces

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Author(s):
Bedatty Fernandes, Flavio C. [1] ; Patil, Amol V. [2] ; Bueno, Paulo R. [1] ; Davis, Jason J. [2]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista, Nanobion Grp, Dept Phys Chem, Inst Chem, UNESP, Sao Paulo State Univ, BR-14800900 Araraquara, SP - Brazil
[2] Univ Oxford, Dept Chem, Oxford OX1 3QZ - England
Total Affiliations: 2
Document type: Journal article
Source: Analytical Chemistry; v. 87, n. 24, p. 12137-12144, DEC 15 2015.
Web of Science Citations: 19
Abstract

Among the numerous label free electronic biomarker assay methodologies now available, impedance based electrochemical capacitance spectroscopy (ECS), based upon mapping the perturbations in interfacial charging of redox elements incorporated into a biologically receptive interface, has recently been shown to be a convenient and highly sensitive mode of transduction and one which, additionally, requires no predoping of analytical solution. We present, herein, a data acquisition and analysis methodology based on frequency resolved immittance function analysis. Ultimately, this enables both a maximization of assay sensitivity and a reduction in assay acquisition time by an order of magnitude. (AU)

FAPESP's process: 15/13359-2 - Sensitive label free detection systems of disease markers for clinical tests using electrochemical immittance
Grantee:Flávio Cesar Bedatty Fernandes
Support Opportunities: Scholarships in Brazil - Post-Doctoral