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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lactobacillus and Lactobacillus cell-free culture supernatants modulate chicken macrophage activities

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Author(s):
Quinteiro-Filho, W. M. [1] ; Brisbin, J. T. [1] ; Hodgins, D. C. [1] ; Sharif, S. [1]
Total Authors: 4
Affiliation:
[1] Univ Guelph, Ontario Vet Coll, Dept Pathobiol, Guelph, ON N1G 2W1 - Canada
Total Affiliations: 1
Document type: Journal article
Source: Research in Veterinary Science; v. 103, p. 170-175, DEC 2015.
Web of Science Citations: 3
Abstract

Lactobacilli are commensal microbes that reside in the intestines of several species, including chickens. Structural constituents of lactobacilli are able to stimulate the host immune system. Macrophages are crucial players in both innate and adaptive immune systems. Here, we investigated the effects of Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus salivarius and their cell-free culture supernatants on the pro-inflammatory gene expression profile, nitric oxide (NO) production and phagocytosis by chicken macrophages. Substantial differences were found among Lactobacillus strains in their capacity to induce pro-inflammatory cytokines. L. acidophilus only up-regulated interferon (IFN)-gamma, while L. reuteri and L. salivarius up-regulated interleukin (IL)-1 beta, IL-6, IL-8 and IL-12 expression. Supernatant of L. salivarius up-regulated IL-1 beta, IL-8 and IFN-gamma expression, while the other cell-free supernatants did not induce significant changes. Moreover, L. reuteri and L. salivarius increased macrophage phagocytosis, but all cell-free supernatants increased macrophage NO production and did not change phagocytosis activity. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/13736-5 - Effects of Lactobacillus salivarius on immunity and intestinal commensal microbiota of heat-stressed broiler chickens infected with Salmonella Enteritidis
Grantee:Wanderley Moreno Quinteiro Filho
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/00987-5 - Effects of Lactobacillus spp. on cytokine, avian defensins e toll-like receptors gene expression of heat-stressed broiler chickens infected with Salmonella Typhimurium
Grantee:Wanderley Moreno Quinteiro Filho
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor