Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Author(s):Show less -

Cunha, G. R. ^{[1, 2, 3]} ; Asevedo, E. ^{[1, 2, 3]} ; Mansur, R. B. ^{[2, 3]} ; Zugman, A. ^{[1, 2, 3]} ; Pan, P. M. ^{[1, 2, 3]} ; Gadelha, A. ^{[1, 2, 3]} ; Belangero, S. I. ^{[1, 2]} ; Rizzo, L. B. ^[1] ; Coelho, R. ^{[4, 5]} ; Stertz, L. ^{[6, 7, 8]} ; Cogo-Moreira, H. ^[1] ; Grassi-Oliveira, R. ^{[4, 5, 2]} ; Teixeira, A. L. ^[9] ; Kauer-Sant'Anna, M. ^{[6, 7]} ; Mari, J. J. ^{[1, 2, 3, 10]} ; Miguel, E. C. ^{[11, 2, 10]} ; Bressan, R. A. ^{[1, 2, 3, 10]} ; Brietzke, E. ^{[1, 2, 3]}

Affiliation:Show less -

^[1] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[2] Natl Inst Dev Psychiat INPD, Sao Paulo - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Program Recognit & Intervent Individuals At Risk, Sao Paulo - Brazil

^[4] Pontificial Catolic Univ Rio Grande do Sul PUCRS, Postgraduat Program Psychol, Porto Alegre, RS - Brazil

^[5] Pontificial Catolic Univ Rio Grande do Sul PUCRS, Dev Cognit Neurosci Res Grp GNCD, Porto Alegre, RS - Brazil

^[6] Fed Univ Rio Grande do Sul UFRGS, Mol Psychiat Unit, Porto Alegre, RS - Brazil

^[7] Fed Univ Rio Grande do Sul UFRGS, Natl Sci & Technol Inst Translat Med INCT TM, Porto Alegre, RS - Brazil

^[8] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, UT Ctr Mol Psychiat, Houston, TX 77030 - USA

^[9] Univ Fed Minas Gerais, Translat Psychoneuroimmunol Grp, Belo Horizonte, MG - Brazil

^[10] Fed Univ Rio Grande do Sul UFRGS, Lab Mol Psychiat, Porto Alegre, RS - Brazil

^[11] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil

• Document type: Journal article
• Source: ACTA PSYCHIATRICA SCANDINAVICA; v. 133, n. 2, p. 122-132, FEB 2016.
• Web of Science Citations: 5

Abstract

Objective: To investigate the association between peripheral biomarkers and child psychopathology in a large community sample. Method: A total of 625 aged 6- to 13-year old subjects were recruited from a community school-based study. Psychopathology was assessed using the Child Behaviour Checklist (CBCL). Psychiatric diagnosis was evaluated using the Development and Well-Being Assessment. The following biomarkers were examined in peripheral blood: brain-derived neurotrophic factor, cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, IFN-g, and TNF-alpha), chemokines (eotaxin/CCL11, IP-10, MCP-1), cytokine receptors (sTNFR1 and sTNFR2), and the oxidative stress marker TBARS. Results: We found significant associations between sTNFR2, eotaxin/CCL11 and CBCL total score, as well as with specific dimensions of psychopathology. There were different patterns of association between these biomarkers and psychological and behavioural symptoms in children with and without a mental disorder. TBARS, IL-6 and MCP-1 were more specific to some clusters of symptoms in children with a psychiatric diagnosis. Conclusion: Our data support the potential use of biomarkers, especially those involved in immune-inflammatory pathways, in investigating neurodevelopmental psychopathology. Their association with different dimensions of symptoms might be of useful when analyzing illness severity and clusters of symptoms within specific disorders. (AU)

• FAPESP's process: 08/57896-8 - National Institute for Developmental Psychiatry
• Grantee: Eurípedes Constantino Miguel Filho
• Support Opportunities: Research Projects - Thematic Grants