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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro cytotoxicity study of ent-kaurenoic acid derivatives against human breast carcinoma cell line

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Author(s):
Simao, Marilia R. [1] ; Carneiro, Luiza J. [1] ; dos Santos, Raquel A. [1] ; Bastos, Jairo K. [2] ; Veneziani, Rodrigo C. S. [1] ; Ambrosio, Sergio R. [1] ; Mizuno, Cassia S. [3]
Total Authors: 7
Affiliation:
[1] Univ Franca, Nucl Pesquisa Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ New England, Dept Pharmaceut Sci, 716 Stevens Ave, Portland, ME 04103 - USA
Total Affiliations: 3
Document type: Journal article
Source: MEDICINAL CHEMISTRY RESEARCH; v. 25, n. 2, p. 303-309, FEB 2016.
Web of Science Citations: 6
Abstract

Kaurenoic acid is a diterpene isolated from copaiba oleo resin. Based on the reported moderate cytotoxic activity of kaurenoic acid, a series of amides and diols derivatives of kaurenoic acid were synthesized and their abilities to inhibit the growth of MCF-7 cells were evaluated. Among the derivatives, compound 2f was the most active with an IC50 of 7.84 A mu M. (AU)

FAPESP's process: 11/23028-2 - Evaluation of biological activity of ent-kaurenoic acid derivatives by biotransformation and semi synthesis
Grantee:Marilia Rodrigues Simão
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants