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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibodies Against Glycolipids Enhance Antifungal Activity of Macrophages and Reduce Fungal Burden After Infection with Paracoccidioides brasiliensis

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Author(s):
Bueno, Renata A. [1, 2] ; Thomaz, Luciana [1] ; Munoz, Julian E. [1] ; da Silva, Cassia J. [1] ; Nosanchuk, Joshua D. [3, 4] ; Pinto, Marcia R. [5] ; Travassos, Luiz R. [6] ; Taborda, Carlos P. [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Med Mycol IMTSP LIM53, Sao Paulo - Brazil
[3] Albert Einstein Coll Med, Dept Med, New York, NY - USA
[4] Albert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY - USA
[5] Univ Fed Fluminense, Niteroi, RJ - Brazil
[6] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: FRONTIERS IN MICROBIOLOGY; v. 7, FEB 3 2016.
Web of Science Citations: 2
Abstract

Paracoccidioidomycosis is a fungal disease endemic in Latin America. Polyclonal antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized yeast forms in vitro increasing phagocytosis and reduced the fungal burden of infected animals. Antibodies to GSL were active in both prophylactic and therapeutic protocols using a murine intratracheal infection model. Pathological examination of the lungs of animals treated with antibodies to GSL showed well-organized granulomas and minimally damaged parenchyma compared to the untreated control. Murine peritoneal macrophages activated by IFN-gamma and incubated with antibodies against acidic GSLs more effectively phagocytosed and killed P brasiliensis yeast cells as well as produced more nitric oxide compared to controls. The present work discloses a novel target of protective antibodies against P brasiliensis adding to other well-studied mediators of the immune response to this fungus. (AU)

FAPESP's process: 11/17267-4 - Evaluation of a vaccine based on peptide-P10 and the therapeutic effect when administrate in combination with antifungal drugs in the fibrose experimental murine model induzed with Paracoccodioides brasiliensis conidia
Grantee:Carlos Pelleschi Taborda
Support Opportunities: Regular Research Grants
FAPESP's process: 13/18655-3 - Paracoccidioides lutzii: development of a therapeutic vaccine from specific antigens for use in vaccine combined with the P10 peptide P. brasiliensis
Grantee:Carlos Pelleschi Taborda
Support Opportunities: Regular Research Grants