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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Profile of Cytokines and Chemokines Triggered by Wild-Type Strains of Rabies Virus in Mice

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Author(s):
Appolinario, Camila Michele [1] ; Allendorf, Susan Dora [1] ; Peres, Marina Gea [1] ; Ribeiro, Bruna Devide [1] ; Fonseca, Clovis R. [1] ; Vicente, Acacia Ferreira [1] ; de Paula Antunes, Joao Marcelo A. [1] ; Megid, Jane [1]
Total Authors: 8
Affiliation:
[1] UNESP Univ Estadual Paulista, Dept Vet Hyg & Publ Hlth, Sch Vet Med & Anim Sci, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: American Journal of Tropical Medicine and Hygiene; v. 94, n. 2, p. 378-383, FEB 2016.
Web of Science Citations: 3
Abstract

Rabies is a lethal infectious disease that causes 55,000 human deaths per year and is transmitted by various mammalian species, such as dogs and bats. The host immune response is essential for avoiding viral progression and promoting viral clearance. Cytokines and chemokines are crucial in the development of an immediate antiviral response; the rabies virus (RABV) attempts to evade this immune response. The virus's capacity for evasion is correlated with its pathogenicity and the host's inflammatory response, with highly pathogenic strains being the most efficient at hijacking the host's defense mechanisms and thereby decreasing inflammation. The purpose of this study was to evaluate the expression of a set of cytokine and chemokine genes that are related to the immune response in the brains of mice inoculated intramuscularly or intracerebrally with two wild-type strains of RABV, one from dog and the other from vampire bat. The results demonstrated that the gene expression profile is intrinsic to the specific rabies variant. The prompt production of cytokines and chemokines seems to be more important than their levels of expression for surviving a rabies infection. (AU)

FAPESP's process: 08/11446-1 - Therapeutical and post exposure efficacy of siRNA and ribavirin in mice experimentally infected with rabies virus originating from dogs and bats
Grantee:Jane Megid
Support Opportunities: Regular Research Grants