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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dorsal raphe nucleus acetylcholine-mediated neurotransmission modulates post-ictal antinociception: The role of muscarinic and nicotinic cholinergic receptors

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Author(s):
de Oliveira, Rithiele Cristina [1] ; de Oliveira, Ricardo [1] ; Biagioni, Audrey Francisco [1] ; Falconi-Sobrinho, Luiz Luciano [1] ; Coimbra, Norberto Cysne [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo FMRP USP, Lab Neuroanat & Neuropsychobiol, Dept Pharmacol, Sch Med Ribeirao Preto, Ave Bandeirantes 3900, BR-14040900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Brain Research; v. 1631, p. 80-91, JAN 15 2016.
Web of Science Citations: 2
Abstract

The dorsal raphe nucleus (DRN) is a key structure of the endogenous pain inhibitory system. Although the DRN is rich in serotoninergic neurons, cholinergic neurons are also found in that nucleus. Both ictal and inter-ictal states are followed by post-ictal analgesia. The present study investigated the role of cholinergic mechanisms in postictal antinociceptive processes using microinjections of atropine and mecamylamine, muscarinic and nicotinic cholinergic receptor antagonists, respectively, in the DRN of rats. Intraperitoneal injection of pentylenetetrazole (PTZ) (at 64 mg/kg) caused tonic and tonic-clonic seizures. The convulsive motor reactions were followed by an increase in pain thresholds, a phenomenon known as post-ictal analgesia. Pre-treatment of the DRN with atropine or mecamylamine at 1 mu g, 3 mu g and 5 mu g/0.2 mu L decreased the post-ictal antinociceptive phenomenon. The present results showed that the post-ictal analgesia was mediated by muscarinic and nicotinic cholinergic receptors in the DRN, a structure crucially involved in the neural network that organises post-ictal hypoalgesia. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/10742-7 - Paresthesia as a new approach of study for panic disorder: basic and clinical research
Grantee:Audrey Franceschi Biagioni
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 08/08955-1 - Involvement of the Dorsal Raphe Nucleus Neural Networks and Serotonergic Neurotransmittion in the Locus Coeruleus in Antinociceptive Processess Induced by Oriented Escape Reaction Evoked by Chemical Stimulation of the Medial Hypothalamus.
Grantee:Audrey Franceschi Biagioni
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/00668-6 - Study of the involvement of cholinergic pathways form tegmentar pedunculopontine nucleus to monoaminergic nuclei of the pain endogenous inhibitory system in the post-ictal antinociception
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants
FAPESP's process: 08/09897-5 - Psychopharmacological study of opioid disinhibitory and GABAergic inhibitory links between the amygdaloid complex and the substantia nigra, pars lateralis: Role on fear eliciated by electrical and chemical stimulation of the inferior colliculus
Grantee:Ricardo de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate