Increased DNA Damage is Related to Maternal Blood Glucose Levels in the Offspring of Women With Diabetes and Mild Gestational Hyperglycemia

Author(s)

Gelaleti, Rafael Bottaro ^[1] ; Damasceno, Debora C. ^[1] ; Santos, Daniele P. ^[2] ; Calderon, Iracema M. P. ^[1] ; Rudge, Marilza V. C. ^[1]

Affiliation

^[1] Univ Estadual Paulista Unesp, Botucatu Med Sch, Dept Gynecol & Obstet, Lab Expt Res Gynecol & Obstet, Botucatu, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Lab Cellular & Mol Endocrinol LIM 25, Postgrad Program Endocrinol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: REPRODUCTIVE SCIENCES; v. 23, n. 3, p. 318-323, MAR 2016.
• Web of Science Citations: 4

Abstract

Objective: This study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH). Methodology: Based on oral glucose tolerance test results and glycemic profiles, 56 pregnant women were allocated into 3 groups: nondiabetes, MGH, and diabetes. The offspring of these women (56 infants) were also evaluated. Maternal peripheral blood and umbilical cord blood samples were collected and processed for biochemical and DNA damage analysis by the comet assay. Results: A positive correlation between maternal blood glucose mean and increased offspring DNA damage levels was observed. Hyperglycemia played a role in offspring DNA damage, but other diabetes-induced complications were also involved. Conclusion: Increased maternal blood glucose levels can lead to increased offspring DNA damage levels. Therefore, the monitoring, control, and treatment of pregnant women with diabetes and MGH are highly important to ensure a risk-free pregnancy and healthy infants. (AU)

• FAPESP's process: 08/06642-6 - Evaluation of pregnant women genotoxicity with positive diagnosis of mild gestational hyperglycaemia
• Grantee: Marilza Vieira Cunha Rudge
• Support Opportunities: Regular Research Grants