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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal Periodontal Disease in Rats Decreases Insulin Sensitivity and Insulin Signaling in Adult Offspring

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Author(s):
Shirakashi, Daisy J. [1] ; Leal, Rosana P. [2] ; Colombo, Natalia H. [1] ; Chiba, Fernando Y. [2] ; Garbin, Clea A. S. [2] ; Jardim, Jr., Elerson G. [3] ; Antoniali, Cristina [1] ; Sumida, Doris H. [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ, Dent Sch Aracatuba, Dept Basic Sci, Sao Paulo, SP - Brazil
[2] Sao Paulo State Univ, Dent Sch Aracatuba, Dept Child & Social Dent, Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ, Dent Sch Aracatuba, Dept Pathol & Propedeut, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Periodontology; v. 84, n. 3, p. 407-414, MAR 2013.
Web of Science Citations: 6
Abstract

Background: Periodontal disease during pregnancy has been recognized as one of the causes of preterm and low-birth-weight (PLBW) babies. Several studies have demonstrated that PLBW babies are prone to developing insulin resistance as adults. Although there is controversy over the association between periodontal disease and PLBW, the phenomenon known as programming can translate any stimulus or aggression experienced during intrauterine growth into physiologic and metabolic alterations in adulthood. The purpose of the present study is to investigate whether the offspring of rats with periodontal disease develop insulin resistance in adulthood. Methods: Ten female Wistar rats were divided into periodontal disease (PED) and control (CN) groups. All rats were mated at 7 days after induction of periodontal disease. Male offspring were divided into two groups: 1) periodontal disease offspring (PEDO; n = 24); and 2) control offspring (CNO; n = 24). Offspring body weight was measured from birth until 75 days. When the offspring reached 75 days old, the following parameters were measured: 1) plasma concentrations of glucose, insulin, fructosamine, lipase, amylase, and tumor necrosis factor-alpha (TNF-alpha); 2) insulin sensitivity (IS); and 3) insulin signal transduction (IST) in insulin-sensitive tissues. Results: Low birth weight was not detected in the PEDO group. However, plasma concentrations of glucose, insulin, fructosamine, lipase, amylase, and TNF-alpha were increased and IS and IST were reduced (P <0.05) in the PEDO group compared with the CNO group. Conclusion: Maternal periodontal disease may induce insulin resistance and reduce IST in adult offspring, but such alterations are not attributable to low birth weight. J Periodontol 2013;84:407-414. (AU)

FAPESP's process: 09/01412-5 - Evaluation of insulin signal transduction in adult rats offspring from female rats with periodontal disease
Grantee:Doris Hissako Matsushita
Support Opportunities: Regular Research Grants