Management considerations for childhood-onset systemic lupus erythematosus patients and implications on therapy

Author(s)

Silva, Clovis Artur ^{[1, 2]} ; Aikawa, Nadia Emi ^{[1, 2]} ; Rodrigues Pereira, Rosa Maria ^[1] ; Arruda Campos, Lucia Maria ^[2]

Affiliation

^[1] Univ Sao Paulo, Fac Med, Div Rheumatol, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, Ave Dr Eneas Carvalho Aguiar, 647 Cerqueira Cesar, BR-05403000 Sao Paulo - Brazil

• Document type: Review article
• Source: EXPERT REVIEW OF CLINICAL IMMUNOLOGY; v. 12, n. 3, p. 301-313, MAR 3 2016.
• Web of Science Citations: 18

Abstract

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory and autoimmune disease that may involve various organs and systems. This narrative review focuses on the recent evidence relating to cSLE management. The general management considerations of cSLE patients require the use of validated classification criteria, disease and health-related quality of life tools evaluation, as well as assessments of lupus nephritis biomarkers and cSLE quality indicators. The drug treatment for cSLE patients includes general supportive care and immunosuppressive therapy. Important implications on cSLE therapy are also updated such as infection, vaccination, infertility, pregnancy, contraception, dyslipidemia, physical activity, cancer, bone health, drug pharmacokinetics, adherence, academic outcomes, transition to adult care and cumulative organ damage. (AU)

• FAPESP's process: 14/14806-0 - Evaluation of ovarian reserve, antibody anti-corpus luteum, cervicovaginal cytology, lower genital tract infections, metabolomics and ovulatory dysfunction in women with juvenile idiopathic arthritis
• Grantee: Clovis Artur Almeida da Silva
• Support Opportunities: Regular Research Grants