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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heart rate variability and plasma biomarkers in patients with type 1 diabetes mellitus: Effect of a bout of aerobic exercise

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Author(s):
Anaruma, Chadi P. [1] ; Ferreira, Jr., Maycon [1] ; Sponton, Carlos H. G. [1] ; Delbin, Maria A. [2] ; Zanesco, Angelina [1]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Rio Claro, SP - Brazil
[2] UNICAMP Univ Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Diabetes Research and Clinical Practice; v. 111, p. 19-27, JAN 2016.
Web of Science Citations: 4
Abstract

Objective: The aim of this study was to evaluate: (1) the cardiovascular parameters and plasma biomarkers in people with type 1 diabetes mellitus (T1DM) at baseline; and (2) the heart rate variability (HRV) and blood glucose in response to a session of aerobic exercise (AE) and during recovery period. Research design and methods: Adults (18-35 years) were divided into two groups: control (CT, n = 10) and T1DM (n = 9). Anthropometric, cardiovascular, and biochemical parameters, and aerobic capacity (indirect peak oxygen uptake, VO2peak) were evaluated at baseline. Thirty minutes of AE (40-60% intensity) was performed on a treadmill. Blood glucose and HRV were determined at rest, during AE, and during the recovery period. Results: Anthropometric measurements, cardiovascular parameters, aerobic capacity, and biochemical parameters were similar between the groups at baseline. In the T1DM group, blood glucose, glycated hemoglobin, and thiobarbituric acid reactive substances concentrations were increased while nitrite/nitrate (NOx-) levels were reduced. During AE, the magnitude of the reduction of blood glucose was greater than that during the recovery period in the T1DM group. The RR intervals and SDNN were reduced at rest as well as in the recovery period in T1DM subjects, whereas the RMSSD and pNN50 were only reduced during the recovery period. No changes were observed in low frequency (LF), high frequency (HF), and LF/HF ratio. Conclusion: Our study shows that T1DM patients on insulin therapy have poor blood glucose control with greater lipid peroxidation and lower NOx- levels, accompanied by an imbalance in autonomic function detected by the challenge of AE. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 13/02960-1 - Role of perivascular adipose tissue in aorta and femoral arteries from trained mice fed with high-fat diet
Grantee:Maria Andréia Delbin
Support Opportunities: Regular Research Grants
FAPESP's process: 11/17437-7 - Effect of exercise training on the cardiovascular and endocrine-metabolic responses in postmenopausal women
Grantee:Angelina Zanesco
Support Opportunities: Regular Research Grants