| Full text | |
| Author(s): |
Yanguas, Sara Crespo
[1]
;
Willebrords, Joost
[1]
;
Maes, Michael
[1]
;
da Silva, Tereza Cristina
[2]
;
Alves Pereira, Isabel Veloso
[2]
;
Cogliati, Bruno
[2]
;
Zaidan Dagli, Maria Lucia
[2]
;
Vinken, Mathieu
[1]
Total Authors: 8
|
| Affiliation: | [1] Vrije Univ Brussel, Fac Med & Pharm, Dept In Vitro Toxicol & Dermatocosmetol, Laarbeeklaan 103, B-1090 Brussels - Belgium
[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Av Prof Dr Orlando Marques de Paiva 87, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | EXCLI JOURNAL; v. 15, p. 177-186, 2016. |
| Web of Science Citations: | 10 |
| Abstract | |
Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these deleterious events connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets. (AU) | |
| FAPESP's process: | 13/50420-6 - Connexin and pannexin channels as drug targets and biomarkers in acute and chronic liver disease |
| Grantee: | Mathieu Frederick Alexander Vinken |
| Support Opportunities: | Research Projects - SPEC Program |