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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Design and Characterization of a Novel p1025 Peptide-Loaded Liquid Crystalline System for the Treatment of Dental Caries

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Author(s):
Fioramonti Calixto, Giovana Maria [1] ; Garcia, Matheus Henrique [1] ; Cilli, Eduardo Maffud [2] ; Chiavacci, Leila Aparecida [1] ; Chorilli, Marlus [1]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut, Campus Araraquara, BR-14800850 Araraquara, SP - Brazil
[2] UNESP Univ Estadual Paulista, Inst Quim, Campus Araraquara, BR-14800900 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Molecules; v. 21, n. 2 FEB 2016.
Web of Science Citations: 12
Abstract

Dental caries, mainly caused by the adhesion of Streptococcus mutans to pellicle-coated tooth surfaces, is an important public health problem worldwide. A synthetic peptide (p1025) corresponding to residues 1025-1044 of the adhesin can inhibit this binding. Peptides are particularly susceptible to the biological environment; therefore, a p1025 peptide-loaded liquid crystalline system (LCS) consisting of tea tree oil as the oil phase, polyoxypropylene-(5)-polyoxyethylene-(20)-cetyl alcohol as the surfactant, and water or 0.5% polycarbophil polymer dispersions as the aqueous phase was employed as a drug delivery platform. This system exhibited anticaries and bioadhesive properties and provided a protective environment to p1025 at the site of action, thereby modulating its action, prolonging its contact with the teeth, and decreasing the frequency of administration. LCSs were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), and rheological, texture, and bioadhesive tests. PLM and SAXS revealed the presence of hexagonal liquid crystalline phases and microemulsions. Rheological analyses demonstrated that the addition of polymer dispersions favored characteristics such as shear thinning and thixotropy, hence improving buccal application. Bioadhesion tests showed that polymer dispersions contributed to the adhesion onto the teeth. Taken together, LCS could provide a novel pharmaceutical nanotechnology platform for dental caries treatment. (AU)

FAPESP's process: 13/01565-1 - Mucoadhesive precursor systems of liquids crystals for buccal admnistration of antigelatinolytic peptide associated with photodynamic therapy in the treatment of oral cancer
Grantee:Giovana Maria Fioramonti Calixto Balian
Support Opportunities: Scholarships in Brazil - Doctorate