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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil

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Author(s):
Pina, Alicia Rumayor [1] ; Jimenez, Laisa Simakawa [2] ; Mariano, Fernanda Viviane [2] ; Benevenuto de Andrade, Bruno Augusto [3] ; Carlos, Roman [4] ; Altemani, Albina [2] ; de Almeida, Oslei Paes [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Piracicaba Dent Sch, Oral Pathol Sect, Dept Oral Diag, Piracicaba - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Pathol, Piracicaba - Brazil
[3] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, Oral Pathol Sect, Rio De Janeiro - Brazil
[4] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala
Total Affiliations: 4
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 121, n. 4, p. 412-418, APR 2016.
Web of Science Citations: 0
Abstract

Objectives. A subgroup of tonsillar squamous cell carcinoma (SCC) is associated with human papillomavirus (HPV). Nevertheless, the prevalence of HPV seems to be variable in different regions and ethnic groups. There are no reports of HPV in tonsillar carcinomas in Guatemala, and data from Brazil are scarce. The aim of this study is to analyze and compare HPV presence in samples of tonsillar SCC from these countries. Study Design. This study describes the histologic features, expression of p16 by immunohistochemistry (IHC), and HPV by in situ hybridization (ISH) in 13 Guatemalan and 13 Brazilian patients. Results. All cases of tonsillar SCC from Guatemala were positive for p16, 92% expressed HPV by ISH, and 75% corresponded to the high-risk genotype 16/18. From the Brazilian patients, only four expressed p16, and all were negative for HPV. Conclusions. Cases from Guatemala, which were mostly nonkeratinizing SCC and originated from the crypt/reticular epithelium of the tonsil, had high-risk integrated HPV, whereas in Brazilian cases, which were mostly keratinizing SCC that originated from the surface epithelium, there was no association with HPV. (AU)

FAPESP's process: 13/14163-9 - Study of prevalence of HPV virus in squamous cell carcinoma of the amygdala in the Brazilian population and its clinicopathological features
Grantee:Laísa Simakawa Jimenez
Support Opportunities: Scholarships in Brazil - Scientific Initiation