| Full text | |
| Author(s): |
Scopim-Ribeiro, Renata
[1, 2]
;
Machado-Neto, Joao Agostinho
[1, 2]
;
Campos, Paula de Melo
[1]
;
Niemann, Fernanda Soares
[1]
;
Lorand-Metze, Irene
[1]
;
Costa, Fernando Ferreira
[1]
;
Olalla Saad, Sara Teresinha
[1]
;
Traina, Fabiola
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Campinas, Hemoctr Unicamp, Inst Nacl Ciencia & Tecnol Sangue, Hematol & Hemotherapy Ctr, Rua Carlos Chagas 480, BR-13083878 Campinas, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Internal Med, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | DIAGNOSTIC PATHOLOGY; v. 11, MAR 16 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
Background: New sequencing technologies have enabled the identification of mutations in Ten-eleven-translocation 2 (TET2), an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) in myeloid neoplasms. We have recently identified reduced TET2 mRNA expression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which is associated with a poor overall survival in MDS. We herein aimed to investigate TET2 mutations and their impact on TET2 expression in a cohort of patients with myeloid neoplasms, including MDS and AML patients. Findings: TET2 mutations were observed in 8 out of 19 patients (42 %) with myeloid neoplasms. The TET2 expression profile was similar between in wild type and in TET2 mutated patients. Conclusion: Our results suggest that TET2 expression is reduced in MDS/AML patients, independently of mutational status. (AU) | |
| FAPESP's process: | 11/51959-0 - Biology of neoplastic diseases of bone marrow |
| Grantee: | Sara Teresinha Olalla Saad |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/15905-3 - DNMT3A mutations, expression and function in myelodysplasic syndromes and acute myeloid leukemia. |
| Grantee: | Renata Scopim Ribeiro |
| Support type: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/09982-8 - Investigation of molecular alterations in myeloid neoplasms. |
| Grantee: | Fabíola Traina |
| Support type: | Regular Research Grants |