Thermal decomposition of tetracycline and chlortetracycline

Author(s)

Cervini, Priscila ^[1] ; Murreli Machado, Luis Carlos ^[1] ; Garcia Ferreira, Ana Paula ^[1] ; Ambrozini, Beatriz ^[1] ; Gomes Cavalheiro, Eder Tadeu ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, Av Trabalhador Sao Carlense 400, Caixa Postal 780, BR-13560970 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS; v. 118, p. 317-324, MAR 2016.
• Web of Science Citations: 10

Abstract

The thermal behavior of tetracycline hydrochloride (TC) and chlortetracycline hydrochloride (CTC) antibiotics was evaluated using thermoanalytical techniques TGA-DTA, DSC and evolved gas analysis by TGA-FTIR, providing information regarding thermal stability, decomposition steps and melting. TGA-FTIR revealed hydrochloric acid, water, isocyanic acid, dimethylamine, methane as main decomposition products for both antibiotics. Ammonia and carbon dioxide from the decomposition of the isocyanic acid have also been detected. According to DSC data the melting process occurred just before decomposition at 220.9 degrees C for TC. Tentative mechanisms for the thermal behavior of TC and CTC are presented. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/09911-3 - Application of thermal analysis to the study of antihypertensives and antibiotics drugs: beta-blockers and tetracyclines
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants