| Full text | |
| Author(s): |
Moura, A. S. A. M. T.
[1]
;
Ledur, M. C.
[2]
;
Boschiero, C.
[3]
;
Nones, K.
[4]
;
Pinto, L. F. B.
[5]
;
Jaenisch, F. R. F.
[2]
;
Burt, D. W.
[6, 7]
;
Coutinho, L. L.
[3]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Paulista, UNESP FMVZ, Dept Anim Prod, BR-18618970 Botucatu, SP - Brazil
[2] Embrapa Suinos & Aves, CP 21, BR-89700000 Concordia, SC - Brazil
[3] USP ESALQ, Dept Zootecnia, CP 09, BR-13418900 Piracicaba, SP - Brazil
[4] QIMR Berghofer Med Res Istitute, 300 Herston Rd, Brisbane, Qld 4006 - Australia
[5] Univ Fed Bahia, Dept Zootecnia, Salvador, BA - Brazil
[6] Univ Edinburgh, Roslin Inst, Div Genet & Genom, Roslin EH25 9PS, Midlothian - Scotland
[7] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian - Scotland
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF APPLIED GENETICS; v. 57, n. 2, p. 215-224, MAY 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
Rapid growth in broilers is associated with susceptibility to metabolic disorders such as pulmonary hypertension syndrome (ascites) and sudden death. This study describes a genome search for QTL associated with relative weight of cardio respiratory and metabolically important organs (heart, lungs, liver and gizzard), and hematocrit value in a Brazilian broiler-layer cross. QTL with similar or different effects across sexes were investigated. At 42 days of age after fasted for 6 h, the F-2 chickens were weighed and slaughtered. Weights and percentages of the weight relative to BW42 of gizzard, heart, lungs, liver and hematocrit were used in the QTL search. Parental, F-1 and F-2 individuals were genotyped with 128 genetic markers (127 microsatellites and 1 SNP) covering 22 linkage groups. QTL mapping analyses were carried out using mixed models. A total of 11 genome-wide significant QTL and five suggestive linkages were mapped. Thus, genome-wide significant QTL with similar effects across sexes were mapped to GGA2, 4 and 14 for heart weight, and to GGA2, 8 and 12 for gizzard %. Additionally, five genome-wide significant QTL with different effects across sexes were mapped to GGA 8, 19 and 26 for heart weight; GGA26 for heart % and GGA3 for hematocrit value. Five QTL were detected in chromosomal regions where QTL for similar traits were previously mapped in other F-2 chicken populations. Seven novel genome-wide significant QTL are reported here, and 21 positional candidate genes in QTL regions were identified. (AU) | |