Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid hormone reduces inflammatory cytokines improving glycaemia control in alloxan-induced diabetic wistar rats

Full text
Author(s):
Panveloski-Costa, A. C. [1] ; Teixeira, S. Silva [1] ; Ribeiro, I. M. R. [1] ; Serrano-Nascimento, C. [1] ; das Neves, R. X. [2] ; Favaro, R. R. [2] ; Seelaender, M. [2] ; Antunes, V. R. [1] ; Nunes, M. T. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Cell & Dev Biol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACTA PHYSIOLOGICA; v. 217, n. 2, p. 130-140, JUN 2016.
Web of Science Citations: 12
Abstract

Aim: This study aimed at evaluating whether thyroid hormone treatment could improve glycaemia and insulin response in alloxan-induced diabetic rats by altering cytokine expression in the skeletal muscle and epididymal white adipose tissue (eWAT) as well as altering inflammatory cell infiltration in eWAT. Methods: Diabetes mellitus (DM) was induced in male Wistar rats by alloxan injection, and a subset of the diabetic rats was treated with T3 (1.5 mu g per 100 g body weight) for a 28-day period (DT3). Cytokines were measured in serum (MILIplex assay kit) as well as in soleus and EDL skeletal muscles and eWAT by Western blotting. Thyroid function was evaluated by morphological, molecular and biochemical parameters. Cardiac function was assessed by measuring heart rate, blood pressure, maximal rate of pressure development (dp/dt(max)) and decline (dp/dt(min)) as well as the contractility index (CI). Sixty rats were used in the study. Results: Diabetic rats exhibited decreased thyroid function and increased inflammatory cytokines in serum, soleus muscle and eWAT. T3 treatment decreased glycaemia and improved insulin sensitivity in diabetic animals. These alterations were accompanied by decreased TNF-alpha and IL-6 content in soleus muscle and eWAT, and inflammatory cell infiltration in eWAT. T3 treatment did not affect cardiac function of diabetic rats. Conclusions: The present data provide evidence that T3 treatment reduces glycaemia and improves insulin sensitivity in diabetic rats, and that at least part of this effect could result from its negative modulation of inflammatory cytokine expression. (AU)

FAPESP's process: 10/18151-7 - Characterization of actions of TH and its agonist GC-1 in the homeostasis glycemic: study in muscle cells and diabetic rats
Grantee:Silvania da Silva Teixeira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/09014-9 - EFFECTS OF THYROID HORMONE IN MODULATING THE EXPRESSION OF CYTOKINES INVOLVED IN INSULIN SIGNALING DURING OBESITY OR DIABETES
Grantee:Ana Carolina Panveloski Costa Salomão
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/05629-4 - Genomic vs nongenomic actions of thyroid hormones: changes of paradigms, physiological implications and therapeutical perspectives
Grantee:Maria Tereza Nunes
Support Opportunities: Research Projects - Thematic Grants