Pharmacologic injection treatment of comitant strabismus

Author(s)

Debert, Iara ^{[1, 2, 3, 4]} ; Miller, Joel M. ^{[2, 3]} ; Danh, Kenneth K. ^{[2, 3]} ; Scott, Alan B. ^{[2, 3]}

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Sao Paulo - Brazil

^[2] Strabismus Res Fdn, Mill Valley, CA - USA

^[3] Eidactics, Med Arts Bldg, Suite 210, 2000 Van Ness Ave, San Francisco, CA 94109 - USA

^[4] Inst Strabos, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF AAPOS; v. 20, n. 2, p. 106-111, APR 2016.
• Web of Science Citations: 7

Abstract

PURPOSE To report the magnitude and stability of corrections in comitant horizontal strabismus achieved by injecting bupivacaine (BPX, optionally with epinephrine) and botulinum A toxin (BTXA) into extraocular muscles of alert adult subjects with electromyographic (EMG) guidance. METHODS A total of 55 adults with comitant horizontal strabismus participated in a prospective observational clinical series. Of these, 29 previously had undergone 1 or more unsuccessful strabismus surgeries; 4 had undergone other orbital surgeries. Thirty-one patients with esodeviations received BPX injections in a lateral rectus muscle, some with BTXA in the medial rectus; 24 patients with exodeviations received BPX in a medial rectus muscle, some with BTXA in the lateral rectus muscle. A second treatment (BPX, BTXA, or both) was administered to 27 patients who had residual strabismus after the first treatment. Five patients required additional injections. Clinical alignment was measured at 6 months and yearly thereafter through 5 years' follow-up, with mean follow-up of 28 months. A successful outcome was defined as residual deviation <= 10(Delta). RESULTS On average, presenting misalignment of 23.8(Delta) (13.4 degrees) was reduced at 28 months by 16.0(Delta) (9.1 degrees), with successful outcomes in 56% of patients. Of patients with initial misalignments <= 25(Delta), 66% had successful outcomes, with corrections averaging 13.2(Delta) (7.5 degrees); of patients with larger misalignments, 40% had successful outcomes, with corrections averaging 20.9(Delta) (11.8 degrees). Corrected alignments were stable over follow-ups as long as 5 years. CONCLUSIONS Injection treatments resulted in stable, clinically significant corrections in comitant horizontal strabismus. Injection provides a low-cost alternative to incisional strabismus surgery, particularly where it is desirable to minimize surgical anesthesia and avoid extraocular scarring. (AU)

• FAPESP's process: 14/06807-6 - Strabismus treatment in children: a model that allows bupivacaine injection of extraocular muscles
• Grantee: Iara Debert
• Support Opportunities: Scholarships abroad - Research