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Cardiovascular and hypertonic NaCl and water intake effects induced by GABAC agonist injected into the lateral parabrachial nucleus (LPBN) in rats

Grant number: 09/03006-4
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): June 30, 2011
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:João Carlos Callera
Grantee:Gean Domingos da Silva Souza
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The lateral parabrachial nucleus (LPBN), a pontine structure is an important area involved in the control of water and sodium intake. Previous studies showed inhibitory serotonergic and cholecystokinergic mechanisms in the LPBN in the control of water and sodium intake. Injections of methysergide, a serotonergic receptor antagonist or proglumide, a cholecystokinin antagonist, into the LPBN increase hypertonic NaCl intake induced by sodium depletion or combined treatment with furosemide and angiotensin converting enzyme inhibitor captopril and increases water intake induced by angiotensin II injected intracerebroventricular. However, methysergide or proglumide into the LPBN in satiated rats not submitted to any other dipsogenic treatment produces no intake of water or NaCl. GABA is an inhibitory neurotransmitter widely distributed in the central nervous system. Until recently, two receptor subtypes were known: bicuculline-sensitive GABAa and baclofen-sensitive GABAb receptors. Several lines of evidence now indicate the existence of a third class of GABA receptor; which is distinct pharmacologically from GABAa and GABAb receptors. These novel GABAc receptors are Cl- pores. They (GABAc receptors) are insensitive to drugs that modulate GABAa and GABAb receptors. Recent studies from our laboratory showed that injections of muscimol (a GABAa agonist) or baclofen (a GABAb agonist) into the LPBN induced hypertonic NaCl and water intake in satiated rats, induced by sodium depletion or hyperosmotic rats. Considering the involvement of central GABAergic mechanisms in the regulation of ingestive behavior, the existence of inhibitory mechanisms in the LPBN to control sodium intake, in the present study we pretend investigated the cardiovascular effects (arterial pressure and heart rate) of a third class of GABA receptors (GABAc receptors). In addition, the effects of the activation of GABAc receptors in the LPBN on water and hypertonic NaCl intake will also tested in satiated or depleted rats induced by injection of furosemide and captopril (FURO+CAP model).

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMINGOS-SOUZ, GEAN; MESCHIARI, CESAR ARRUDA; BUZELLE, SAMYRA LOPES; CALLERA, JOAO CARLOS; ANTUNES-RODRIGUES, JOSE. Sodium and water intake are not affected by GABA(C) receptor activation in the lateral parabrachial nucleus of sodium-depleted rats. Journal of Chemical Neuroanatomy, v. 74, p. 47-54, JUL 2016. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Gean Domingos da Silva. Efeitos cardiovasculares e na ingestão de NaCl 1,8% e água induzida pela injeção de trans-4-aminocrotonic acid (TACA) no núcleo parabraquial lateral (NPBL) de ratos. 2011. 74 f. Master's Dissertation - Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Araçatuba.

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