| Full text | |
| Author(s): |
Nasario, Fabio D.
[1]
;
Cazetta, Tarcila
[1]
;
Moran, Paulo J. S.
[1]
;
Rodrigues, J. Augusto R.
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Chem, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | TETRAHEDRON-ASYMMETRY; v. 27, n. 9-10, p. 404-409, JUN 1 2016. |
| Web of Science Citations: | 7 |
| Abstract | |
(R)-1-Arylethanols and other secondary alcohols were prepared at high ee (>90%) by oxidative kinetic resolution using resting cells of the yeast Candida albicans CCT 0776. The deracemization process of 1-phenylethanol la catalyzed by the yeast was elucidated by studying each step separately. It was determined that the reaction occurred via cyclic deracemization, to give (R)-1a in 89% yield and with 98% ee. Finally, deracemization by stereoinversion of rac-1a was studied using a tandem process of C. albicans followed by Lactobacillus brevis CCT 3745. Inverting the sequence of these microorganisms produced an enantiomerically pure antipode. (C) 2016 Published by Elsevier Ltd. (AU) | |
| FAPESP's process: | 14/00108-9 - Application of biocatalysis in organic synthesis using whole cells of microorganisms |
| Grantee: | José Augusto Rosário Rodrigues |
| Support Opportunities: | Regular Research Grants |