Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Postnatal Development of Mongolian Gerbil Female Prostate: An Immunohistochemical and 3D Modeling Study

Full text
Author(s):
Sanches, Bruno D. A. [1] ; Zani, Bruno C. [2] ; Maldarine, Juliana S. [2] ; Biancardi, Manoel F. [3] ; Santos, Fernanda C. A. [3] ; Goes, Rejane M. [2] ; Vilamaior, Patricia S. L. [2] ; Taboga, Sebastiao R. [2]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Ave Bertrand Russel S-N, Campinas, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Biol, Lab Microscopy & Microanal, Rua Cristovao Colombo, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Fed Goias, Dept Morphol, Samambaia 2, Goiania, Go - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MICROSCOPY RESEARCH AND TECHNIQUE; v. 79, n. 5, p. 438-446, MAY 2016.
Web of Science Citations: 5
Abstract

The development of the prostate in male rodents, which involves complex epithelial-mesenchymal interactions between the urogenital sinus epithelium (UGE) and the urogenital sinus mesenchyme (UGM), has been deeply studied. In females, however, this process is not very clear. In this study, the postnatal development of the prostate in female Mongolian gerbils employing three-dimensional (3D) reconstructions, histochemical, and immunohistochemical techniques was characterized. It was observed that prostatic branching and differentiation in females was induced by a single mesenchyme localized at a ventrolateral position, which was named as ventrolateral mesenchyme (VLM); furthermore, the canalization of solid buds began on the third postnatal day (P3) and the branching morphogenesis on P5. We observed secretions in the acini at the end of the first month, and, on P45, the acini were completely differentiated. The strong cell proliferation phase in the first week coincided with the mesenchymal expression of estrogen receptor 1 (ESR1). The expression of androgen receptor (AR) paralleled cell differentiation, and, on P30, immunolabelling with p63 was restricted to basal cells. This study serves as a baseline parameter for future research on disruptions that could affect the development of the female prostate. (C) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process: 13/15939-0 - Evaluation of intrauterine oestrogenic exposure on the main epithelium-mesenchyme interaction pathways in the branching morphogenesis in the Mongolian Gerbil prostrate ventral lobe
Grantee:Bruno Domingos Azevedo Sanches
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/16443-9 - Descriptive study of the branching process of Mongolian gerbil (Meriones unguiculatus) prostate ventral lobe
Grantee:Bruno Casagrande Zani
Support Opportunities: Scholarships in Brazil - Scientific Initiation