Population variation of HLA genes in rural communities in Brazil, the Quilombos from the Vale do Ribeira, Sao Paulo - Brazil

Author(s)

Nunes, Kelly ^[1] ; Piovezan, Bruno ^[2] ; Torres, Margareth A. ^[2] ; Pontes, Gerlandia N. ^[2] ; Kimura, Lilian ^[1] ; Carnavalli, Juliana E. P. ^[1] ; Mingroni Netto, Regina Celia ^[1] ; Moraes, Maria Elisa ^[2] ; Meyer, Diogo ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil

^[2] JRM Invest Imunol, Rio De Janeiro - Brazil

• Document type: Journal article
• Source: HUMAN IMMUNOLOGY; v. 77, n. 6, p. 447-448, JUN 2016.
• Web of Science Citations: 2

Abstract

In the present study, we characterized the allelic and haplotypic profile of the genes HLA-A, -B, -C and -DRB1 (PCR-SBT) in a population sample of 144 highly admixed individuals, coming from rural communities in Brazil (Quilombos from Vale do Ribeira, in the State of Sao Paulo). Furthermore, we identified three individuals with a new null allele in the HLA-C gene (HLA-C{*}02:105N), associated with the haplotype HLA-A{*}80: 01 similar to 13018: 01:01G similar to DRB1{*} 07:01. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 12/18010-0 - Balancing selection in the human genome: detection, causes and consequences
• Grantee: Diogo Meyer
• Support type: Regular Research Grants
• FAPESP's process: 12/09950-9 - Evolution of HLA genes: population differentiation and signatures of recent selection in native and admixed populations from Brazil
• Grantee: Kelly Nunes
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
• Grantee: Mayana Zatz
• Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC