Oral Infections and Cytokine Levels in Patients with Alzheimer's Disease and Mild Cognitive Impairment Compared with Controls

Author(s)

Ferrari Cestari, Jose Augusto ^[1] ; Campos Fabri, Gisele Maria ^{[2, 3]} ; Kalil, Jorge ^[4] ; Nitrini, Ricardo ^[1] ; Jacob-Filho, Wilson ^[5] ; Tesseroli de Siqueira, Jose Tadeu ^[3] ; Siqueira, Silvia Regina D. T. ^{[1, 3, 6]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Neurol, BR-05508 Sao Paulo - Brazil

^[2] Univ Fed Juiz de Fora, Juiz de Fora - Brazil

^[3] Univ Sao Paulo, Sch Med, Hosp Clin, Orofacial Pain Team, Dent Div, BR-05508 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Lab Med Invest Immunol, BR-05508 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Dept Clin Med, Geriatr Clin, BR-05508 Sao Paulo - Brazil

^[6] Univ Sao Paulo, Sch Arts Sci & Med, Gerontol, BR-05508 Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 52, n. 4, p. 1479-1485, 2016.
• Web of Science Citations: 10

Abstract

Background: Oral infections are prevalent in the adult population. Their impact includes the implication as a risk factor for Alzheimer's disease (AD), altering its progression. One of the potential mechanisms involves immune mediators such as circulating cytokines. Objective: The goal of the present study was to investigate the prevalence of oral infections and blood levels of IL-1 beta, TNF-alpha, and IL-6 in patients with AD, mild cognitive impairment (MCI), and controls. Methods: Sixty-five elderly were evaluated (25 AD, 19 MCI, and 21 controls) by the following methods: Mini Mental State Exam, Questionnaire of Functional Activities, periodontal and oral evaluation, and blood concentrations of IL-1 beta, TNF-alpha and IL-6. Results: Patients with AD had high serum IL-6 levels (p = 0.029), and patients with periodontitis had high serum TNF-alpha levels (p = 0.005). There was an association between IL-6 and TNF-alpha in patients with AD/MCI and periodontitis (p = 0.023). Conclusion: The increased levels of TNF-alpha and IL-6 in this study suggests their implication in the overlapping mechanisms between oral infections and AD. Longitudinal studies are necessary for further investigation. (AU)

• FAPESP's process: 11/18756-9 - Mild cognitive impairment and Alzheimer's disease: prevalence of oral infection and seric levels of inflammatory parameters
• Grantee: Silvia Regina Dowgan Tesseroli de Siqueira
• Support Opportunities: Regular Research Grants