Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach

Author(s)

Guiraldello, Rafael T. ^[1] ; Martins, Marcelo L. ^[2] ; Mancera, Paulo F. A. ^[1]

Affiliation

^[1] Univ Estadual Paulista, Dept Bioestat, BR-18618689 Botucatu, SP - Brazil

^[2] Univ Fed Vicosa, Dept Fis, BR-36570900 Vicosa, MG - Brazil

• Document type: Journal article
• Source: PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS; v. 456, p. 145-156, AUG 15 2016.
• Web of Science Citations: 0

Abstract

We present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 09/15098-0 - Assessing control of epidemics using mathematical and computer models
• Grantee: Hyun Mo Yang
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/08133-0 - Mathematical modelling in cancer
• Grantee: Paulo Fernando de Arruda Mancera
• Support Opportunities: Regular Research Grants