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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate

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Author(s):
Gomes, F. C. [1] ; Chuffa, L. G. A. [1] ; Scarano, W. R. [2] ; Pinheiro, P. F. F. [1] ; Favaro, W. J. [3, 2] ; Domeniconi, R. F. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista UNESP, Inst Biosci, Dept Anat, Botucatu, SP - Brazil
[2] Univ Estadual Paulista UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[3] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ANDROLOGY; v. 4, n. 3, p. 473-480, MAY 2016.
Web of Science Citations: 4
Abstract

Age is a key factor in the development of prostatic lesions. An increase in reactive oxygen species levels occurs during aging. Furthermore, the indiscriminate use of anabolic androgenic steroids and physical exercise alter the availability of hormones and may promote the appearance of lesions. This study examined whether the use of nandrolone decanoate (ND), associated or not with resistance exercise training, affects the pathways related to the inflammatory response in the ventral prostate of adult and aged rats. Sprague-Dawley rats were distributed into eight experimental groups: sedentary with ND, sedentary without ND, exercise with ND, and exercise without ND. The animals performed resistance exercise training and received ND two times/week (5mg/kg, i.m.) for 8weeks. Adult rats were killed immediately following treatment completion, and aged rats remained untreated until reaching 300days of age. The adult animals that received ND and performed resistance exercise training showed a higher occurrence of lesions with TLR4 activation. Marked IL-6 expression occurred in the group that performed resistance exercise training. The group exposed to ND showed overexpression of TLR2, TLR4, NOX1, Nrf2, TNF-, and P38MAPK. The animals that received ND and performed training showed increase levels of NFB, IRF3, IL-6, TNF-, and NOX1. TLR2 and TLR4 showed no upregulation in the aged animals. The groups exercise+ND showed lesions in the adult stage and after aging, followed by molecular alterations. We concluded that nandrolone decanoate and resistance exercise training can promote the onset of prostatic tumors in the adult stage, and during aging, activating pathways involved in the inflammatory response. (AU)

FAPESP's process: 13/07203-4 - Histopathological, biochemical and molecular analyzes on the effect of physical exercise and high doses of nandrolone Deconoate during the post-pubertal on aging rat prostates
Grantee:Raquel Fantin Domeniconi
Support Opportunities: Regular Research Grants
FAPESP's process: 13/00649-7 - Histopathological, biochemical and molecular analyzes on the effect of physical exercise and high doses of Nandrolone Deconoate during the post-pubertal on aging rat prostates
Grantee:Fabiana de Campos Gomes
Support Opportunities: Scholarships in Brazil - Master