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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Regulation of neural stem cells by choroid plexus cells population

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Author(s):
Roballo, Kelly C. S. [1] ; Goncalves, Natalia J. N. [1] ; Pieri, Naira C. G. [2] ; Souza, Aline F. [2] ; Andrade, Andre F. C. [3] ; Ambrosio, Carlos E. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Av Duque de Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil
[2] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Surg, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Anim Reprod, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Neuroscience Letters; v. 626, p. 35-41, JUL 28 2016.
Web of Science Citations: 3
Abstract

The choroid plexus is a tissue on the central nervous system responsible for producing cerebrospinal fluid, maintaining homeostasis and neural stem cells support; though, all of its functions still unclear. This study aimed to demonstrate the niches of choroid plexus cells for a better understanding of the cell types and functions, using the porcine as the animal model. The collected material was analyzed by histology, immunohistochemistry, and cell culture. The cell culture was characterizated by immunocytochemistry and flow cytometry. Our results showed OCT-4, TUBIII, Nestin, CD45, CD73, CD90 positive expression and GFAP, CD105 negative expression, also methylene blue histological staining confirmed the presence of telocytes cells. We realized that the choroid plexus is a unique and incomparable tissue with different niches of cells as pluripotent, hematopoietic, neuronal progenitors and telocyte cells, which provide its complexity, differentiated functionality and responsibility on brain balance and neural stem cells regulation. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 15/17897-9 - Exosomal communication in the stem cells transdifferentiation in co-culture with neuronal cells
Grantee:Kelly Cristine Santos Roballo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/07673-0 - Characterization of cells from choroid plexus using as swine animal model
Grantee:Kelly Cristine Santos Roballo
Support Opportunities: Scholarships in Brazil - Scientific Initiation