A new model of hypertension: the offspring of diabetic mother-similarities to SHR ...
| Full text | |
| Author(s): |
Guilherme Santos da Silva Junior
;
Silvia Regina Moreira
;
Sonia K. Nishida
;
Nelson Sass
;
Gianna Mastroianni Kirsztajn
Total Authors: 5
|
| Document type: | Journal article |
| Source: | J. Bras. Nefrol.; v. 38, n. 2, p. 191-202, Jun. 2016. |
| Abstract | |
Abstract Introduction: Renal involvement in pregnant women with chronic hypertension is not widely known. Objectives: 1- To describe the epidemiological profile of pregnant women with chronic hypertension; 2- To evaluate urinary abnormalities (by urinalysis), renal function (serum creatinine and cystatin C, and estimated glomerular filtration rate (eGFR); 3- To evaluate the pregnancy outcome in chronic hypertension. Methods: 103 pregnant women with chronic hypertension (blood pressure over 140/90 mmHg, detected previously to pregnancy or until the 20th week) were submitted to clinical and laboratorial evaluation. Results: Pregnant women were 21-45 (mean: 34) years-old. Protein/creatinine ratio in random urine was elevated in 5.2% (0.0-6.4g/g), serum creatinine in 19.6% and cystatin C in 14.7% of them. It was observed that characteristics of pregnant patients and their newborns (vs. frequencies of the cases with CKD-EPI cystatin C < 60 ml/min/1.73 m2) were: 20.5% (33.3%) of preterm birth < 37 weeks, 17.5% (22.2%) of birth weight < 2500g and 17.5% (22.2%) of small for gestational age; superimposed preeclampsia-eclampsia occurred in 24.7% (22.2%) of the cases. Conclusions: Renal abnormalities were detected by proteinuria, determinations of serum creatinine and cystatin C in 5.2, 19.6 and 14.7% of the cases. The results suggest that the formulas CKD-EPI and MDRD can have applicability in assessing renal function in pregnant women. It was also shown a high frequency of preterm birth or with < 2500g at birth or small for gestational age, as well as of superimposed preeclampsia-eclampsia (24.7%) in pregnant women with chronic hypertension. (AU) | |
| FAPESP's process: | 14/00213-7 - Preeclampsia: future risk of chronic kidney disease and cardiovascular injury |
| Grantee: | Nelson Sass |
| Support type: | Regular Research Grants |