Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series

Author(s)

Estofolete, Cassia Fernanda ^[1] ; Bernardes Terzian, Ana Carolina ^[1] ; Parreira, Ricardo ^[2] ; Esteves, Aida ^[2] ; Hardman, Lucas ^[1] ; Greque, Gilmar Valdir ^[3] ; Rahal, Paula ^[4] ; Nogueira, Mauricio Lacerda ^[1]

Affiliation

^[1] Sao Jose do Rio Preto Sch Med FAMERP, Ave Brigadeiro Faria Lima, 5416 Vila Sao Pedro, BR-15090000 Sao Jose Do Rio Preto - Brazil

^[2] Univ Nova Lisboa, Global Hlth & Trop Med GHTM, Rua Junqueira 100, P-1349008 Lisbon - Portugal

^[3] Sao Jose do Rio Preto Reg Sch Med Fdn FUNFARME, Ave Brigadeiro Faria Lima, 5416 Vila Sao Pedro, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[4] Sao Paulo State Univ, Sao Jose do Rio Preto IBILCE UNESP, Inst Biosci Letters & Exact Sci, Dept Biol, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: Journal of Clinical Virology; v. 81, p. 25-30, AUG 2016.
• Web of Science Citations: 22

Abstract

Background: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. Objective: To identify clinical symptoms of Zika in patients in Dengue suspected patients. Study design: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for <= 5 days, from January to February 2016. Results: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. Conclusion: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
• Grantee: Maurício Lacerda Nogueira
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil
• Grantee: Ana Carolina Bernardes Terzian
• Support Opportunities: Scholarships in Brazil - Post-Doctoral